Research groups
Lars Fugger
Professor of Neuroimmunology
Research Summary
Multiple sclerosis (MS) is a common chronic inflammatory and degenerative disease of the central nervous system. Inherited susceptibility to MS is primarily associated with certain MHC genes. In addition, unknown environmental factors also seem to play a role in the disease. Our group is seeking to understand the molecular basis for the MHC association in MS and how MHC genes interact with environmental factors such as viruses. We are also investigating how the MHC associated inflammation leads to neurodegeneration, which is responsible for the long-term disability in MS patients. We are taking a multidisciplinary approach which is possible through a strong network of local and international collaborators. There is a strong focus on translational medicine and both clinicians and non-clinicians are working in the group.
Recent publications
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Inflammation-related plasma and CSF biomarkers for multiple sclerosis.
Journal article
Huang J. et al, (2020), Proc Natl Acad Sci U S A, 117, 12952 - 12960
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A novel neurodegenerative spectrum disorder in patients with MLKL deficiency.
Journal article
Faergeman SL. et al, (2020), Cell Death Dis, 11
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Identifying cross-disease components of genetic risk across hospital data in the UK Biobank.
Journal article
Cortes A. et al, (2020), Nat Genet, 52, 126 - 134
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B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2.
Journal article
du Pré MF. et al, (2019), The Journal of experimental medicine
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A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity.
Journal article
Ooi JD. et al, (2019), Nat Commun, 10