Laurence Brown
BSc PhD
Senior Postdoctoral Research Associate
I am an experienced neuroscientist, with a multidisciplinary skill-base. I am currently working to Identifying genes involved in circadian function using in-house and public microarray data and developing new methods for measuring activity and behaviour.
Across the animal and plant kingdoms the tailoring of activity to the day or night has repeatedly been shown to provide evolutionary advantages. The core components of the transcription/translation feedback-loop that comprise the clock are found in almost all cells and different stimuli can act as zeitgebers (time-givers). The multiple 'body clocks' in different tissues are now known to be essential for many physiological processes and disruption of their rhythms is often implicated in disease.
Key publications
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COMPASS: Continuous Open Mouse Phenotyping of Activity and Sleep Status
Journal article
Brown LA. et al, (2016), Wellcome Open Research, 1, 2 - 2
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Meta-analysis of transcriptomic datasets identifies genes enriched in the mammalian circadian pacemaker
Journal article
Brown LA. et al, (2017), Nucleic Acids Research, 45, 9860 - 9873
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The CRTC1-SIK1 Pathway Regulates Entrainment of the Circadian Clock
Journal article
Jagannath A. et al, (2013), Cell, 154, 1100 - 1111
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Nicotinic Acetylcholine Receptor Signalling: Roles in Alzheimer's Disease and Amyloid Neuroprotection
Journal article
Buckingham SD. et al, (2009), Pharmacological Reviews, 61, 39 - 61
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Neurovascular relationships in hippocampal slices: physiological and anatomical studies of mechanisms underlying flow-metabolism coupling in intraparenchymal microvessels
Journal article
Lovick TA. et al, (1999), Neuroscience, 92, 47 - 60
Recent publications
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Deletion of AMPA receptor GluA1 subunit gene (Gria1) causes circadian rhythm disruption and aberrant responses to environmental cues
Journal article
Ang G. et al, (2021), Translational Psychiatry, 11
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Dim light in the evening causes coordinated realignment of circadian rhythms, sleep, and short-term memory
Journal article
Tam SKE. et al, (2021), Proceedings of the National Academy of Sciences, 118
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Light Input to the Mammalian Circadian Clock
Journal article
Dannerfjord AA. et al, (2021), 233 - 247
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Simultaneous Assessment of Circadian Rhythms and Sleep in Mice Using Passive Infrared Sensors: A User's Guide.
Journal article
Brown LA. et al, (2020), Curr Protoc Mouse Biol, 10
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Forward genetics identifies a novel sleep mutant with sleep state inertia and REM sleep deficits.
Journal article
Banks GT. et al, (2020), Sci Adv, 6