Contact information

Email	natalie.voets@ndcn.ox.ac.uk
Tel

Biography

Sources of Funding

Medical Research Council
British Medical Association
John Fell Fund
OHBA
Medical Research Fund
HDH Wills 1965 Charitable Trust

My connections

Epilepsy Imaging Research Group Research Group
Glioma Neurosurgery Research Group Research Group

Short Description

D.Phil PROJECTS / RESEARCH PLACEMENTS

Thank you for your interest in our research group. All our D.Phil project positions are currently filled.

Sadly we are unable to offer research internships, shadowing, or other work experience placements due to limited space.

News and updates

Congratulations to Tim for his paper on micro bleeds in the very acute phase following head trauma. Available open access from Neuroscience Letters (direct access here).

Natalie Voets

Research Fellow, FMRIB Centre, Wellcome Centre for Integrative Neuroimaging

Research Summary

Our translational research uses non-invasive brain imaging measures to understand how chronic disease, particularly drug-resistant epilepsy and tumours, affects how the brain represents and processes information relevant to memory and other cognitive functions.

Focused on understanding mechanisms driving brain plasticity and behaviour, our research ultimately aims to improve individual patient management by identifying specific brain patterns predictive of clinical outcome after brain surgery. Accordingly, our multidisciplinary research, based at the FMRIB Centre, is conducted in close collaboration with both the Oxford Epilepsy Surgery Programme and Oncology neurosurgical service as well as neuroscientists at the Oxford Centre for Human Brain Activity.

Additional translational interests include the effects of head trauma on the brain's structural and functional networks, a project spearheaded by one of my D.Phil students, consultant neurosurgeon Tim Lawrence.

Biography

I am a Research Fellow at the FMRIB Centre (now part of the new Wellcome Centre for Integrative Neuroimaging) setting up a dedicated translational imaging group applied to neurosurgical problems, particularly temporal lobe epilepsy and brain tumours.

I studied Experimental Psychology at Oxford (1999-2002) before completing a D.Phil at the FMRIB Centre (2002-2005) under the supervision of Prof. Paul Matthews focused on Temporal Lobe Epilepsy. Following a post-doctoral position with Prof. Tipu Aziz’s Deep Brain Stimulation research group, I spent 3 years as imaging scientist at the GlaxoSmithKline Clinical Imaging Centre (now Imanova), assessing the sensitivity of multi-modal neuroimaging measures as early markers of efficacy for drugs targeting memory impairment among others. In 2009, I moved to the MNI to work in the NeuroImaging of Epilepsy laboratory before returning to the Oxford FMRIB Centre on a MRC Fellowship later that year.

Early detection of cerebral microbleeds following traumatic brain injury using MRI in the hyper-acute phase.
Lawrence TP. et al, (2017), Neurosci Lett, 655, 143 - 150
Ultra-High-Field fMRI Reveals a Role for the Subiculum in Scene Perceptual Discrimination.
Hodgetts CJ. et al, (2017), J Neurosci, 37, 3150 - 3159
Resting connectivity predicts task activation in pre-surgical populations.
Parker Jones O. et al, (2017), Neuroimage Clin, 13, 378 - 385
Donepezil Enhances Frontal Functional Connectivity in Alzheimer's Disease: A Pilot Study.
Griffanti L. et al, (2016), Dement Geriatr Cogn Dis Extra, 6, 518 - 528
Improved localisation for 2-hydroxyglutarate detection at 3T using long-TE semi-LASER.
Berrington A. et al, (2016), Tomography, 2, 94 - 105
Noninvasive Quantification of 2-Hydroxyglutarate in Human Gliomas with IDH1 and IDH2 Mutations.
Emir UE. et al, (2016), Cancer Res, 76, 43 - 49
Thalamo-Cortical Disruption Contributes to Short-Term Memory Deficits in Patients with Medial Temporal Lobe Damage.
Voets NL. et al, (2015), Cereb Cortex, 25, 4584 - 4595
In response: Naming and recognition after laser amygdalohippocampotomy: Is the hippocampus involved?
Drane DL. et al, (2015), Epilepsia, 56, 1318 - 1319
Better object recognition and naming outcome with MRI-guided stereotactic laser amygdalohippocampotomy for temporal lobe epilepsy
Drane DL. et al, (2015), Epilepsia, 56, 101 - 113
Better object recognition and naming outcome with MRI-guided stereotactic laser amygdalohippocampotomy for temporal lobe epilepsy.
Drane DL. et al, (2015), Epilepsia, 56, 101 - 113
Minimally invasive endoscopic resection of intraparenchymal brain tumors.
Plaha P. et al, (2014), World Neurosurg, 82, 1198 - 1208
Differential tangential expansion as a mechanism for cortical gyrification.
Ronan L. et al, (2014), Cereb Cortex, 24, 2219 - 2228
Study protocol: The Whitehall II imaging sub-study.
Filippini N. et al, (2014), BMC Psychiatry, 14
Aberrant functional connectivity in dissociable hippocampal networks is associated with deficits in memory.
Voets NL. et al, (2014), J Neurosci, 34, 4920 - 4928
Minimally invasive endoscopic resection of intraparenchymal brain tumors
Plaha P. et al, (2014), World Neurosurgery, 82, 1198 - 1208
Faciobrachial dystonic seizures: the influence of immunotherapy on seizure control and prevention of cognitive impairment in a broadening phenotype.
Irani SR. et al, (2013), Brain, 136, 3151 - 3162
STEREOTACTIC LASER ABLATION OF HIPPOCAMPUS LEADS TO BETTER COGNITIVE OUTCOME THAN STANDARD TEMPORAL LOBE RESECTION FOR THE TREATMENT OF EPILEPSY
Drane DL. et al, (2013), EPILEPSIA, 54, 20 - 20
Gyrification of Broca's region is anomalously lateralized at onset of schizophrenia in adolescence and regresses at 2 year follow-up.
Palaniyappan L. et al, (2013), Schizophr Res, 147, 39 - 45
Gyrification of Broca's region is anomalously lateralized at onset of schizophrenia in adolescence and regresses at 2year follow-up
Palaniyappan L. et al, (2013), Schizophrenia Research, 147, 39 - 45
Famous face identification in temporal lobe epilepsy: Support for a multimodal integration model of semantic memory
Drane DL. et al, (2013), Cortex, 49, 1648 - 1667
Famous face identification in temporal lobe epilepsy: support for a multimodal integration model of semantic memory.
Drane DL. et al, (2013), Cortex, 49, 1648 - 1667
Consistency and interpretation of changes in millimeter-scale cortical intrinsic curvature across three independent datasets in schizophrenia.
Ronan L. et al, (2012), Neuroimage, 63, 611 - 621
Structural substrates for resting network disruption in temporal lobe epilepsy.
Voets NL. et al, (2012), Brain, 135, 2350 - 2357
Diffusion imaging of whole, post-mortem human brains on a clinical MRI scanner.
Miller KL. et al, (2011), Neuroimage, 57, 167 - 181
Increased temporolimbic cortical folding complexity in temporal lobe epilepsy.
Voets NL. et al, (2011), Neurology, 76, 138 - 144
Functional and structural changes in the memory network associated with left temporal lobe epilepsy.
Voets NL. et al, (2009), Hum Brain Mapp, 30, 4070 - 4081
Anatomical imaging: Volumetric analysis
Voets NL., (2009), Imaging in CNS Drug Discovery and Development: Implications for Disease and Therapy, 31 - 45
Reduced limbic connections may contraindicate subgenual cingulate deep brain stimulation for intractable depression.
McNab JA. et al, (2009), J Neurosurg, 111, 780 - 784
Evidence for abnormalities of cortical development in adolescent-onset schizophrenia.
Voets NL. et al, (2008), Neuroimage, 43, 665 - 675
Connectivity of the human pedunculopontine nucleus region and diffusion tensor imaging in surgical targeting.
Muthusamy KA. et al, (2007), J Neurosurg, 107, 814 - 820
Connectivity of an effective hypothalamic surgical target for cluster headache.
Owen SL. et al, (2007), J Clin Neurosci, 14, 955 - 960
Anatomically related grey and white matter abnormalities in adolescent-onset schizophrenia.
Douaud G. et al, (2007), Brain, 130, 2375 - 2386
Distinct right frontal lobe activation in language processing following left hemisphere injury.
Voets NL. et al, (2006), Brain, 129, 754 - 766
Effect of sildenafil citrate on CBF and BOLD activation in multiple sclerosis patients
Manson SC. et al, (2005), MULTIPLE SCLEROSIS, 11, S59 - S59
Clinical applications of functional magnetic resonance imaging
Voets NL. and Matthews PM., (2005), Imaging Decisions MRI, 9, 16 - 22
Brain white matter fibre tracts: a review of functional neuro-oncological relevance
Voets NL. et al, Journal of Neurology, Neurosurgery & Psychiatry, jnnp-2017-316170 - jnnp-2017-316170

Selected Highlights

Resting connectivity predicts task activation in pre-surgical populations.
Parker Jones O. et al, (2017), Neuroimage Clin, 13, 378 - 385
Thalamo-Cortical Disruption Contributes to Short-Term Memory Deficits in Patients with Medial Temporal Lobe Damage.
Voets NL. et al, (2015), Cereb Cortex, 25, 4584 - 4595
Aberrant functional connectivity in dissociable hippocampal networks is associated with deficits in memory.
Voets NL. et al, (2014), J Neurosci, 34, 4920 - 4928
Structural substrates for resting network disruption in temporal lobe epilepsy.
Voets NL. et al, (2012), Brain, 135, 2350 - 2357

Recent Publications

Early detection of cerebral microbleeds following traumatic brain injury using MRI in the hyper-acute phase.
Lawrence TP. et al, (2017), Neurosci Lett, 655, 143 - 150
Ultra-High-Field fMRI Reveals a Role for the Subiculum in Scene Perceptual Discrimination.
Hodgetts CJ. et al, (2017), J Neurosci, 37, 3150 - 3159
Resting connectivity predicts task activation in pre-surgical populations.
Parker Jones O. et al, (2017), Neuroimage Clin, 13, 378 - 385
Donepezil Enhances Frontal Functional Connectivity in Alzheimer's Disease: A Pilot Study.
Griffanti L. et al, (2016), Dement Geriatr Cogn Dis Extra, 6, 518 - 528
Improved localisation for 2-hydroxyglutarate detection at 3T using long-TE semi-LASER.
Berrington A. et al, (2016), Tomography, 2, 94 - 105
Noninvasive Quantification of 2-Hydroxyglutarate in Human Gliomas with IDH1 and IDH2 Mutations.
Emir UE. et al, (2016), Cancer Res, 76, 43 - 49

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