Research Outlook
Research groups
Colleges
Pao-Sheng Chang
DPhil MRes BSc
Guarantors of Brain Postdoctoral Research Fellow
Education
DPhil Clinical Neurosciences, University of Oxford
MRes Translational Neurology, UCL
BSc Life Science, National Tsing Hua University
Self Intro
Dr Pao-Sheng (Paul) Chang is a committed postdoctoral research fellow funded by Guarantors of Brain (2025-2028). He has obtained solid scientific training since his DPhil period in University of Oxford.
His fellowship research project aims to investigate the specific role of glucocorticoid-induced macrophage subpopulation (MGC) in the development of human neuropathic pain with using a humanised co-culture model system and human injured nerves.
There are four objectives of his fellowship research project:
- Characterize the effects of human MGC on the excitability of injured human induced pluripotent stem cell-derived sensory neurons (hiPSCdSN) in vitro
- Assess the phenotypic changes of macrophage subpopulations after interacting with injured hiPSCdSN in vitro
- Decipher the transcriptomic signatures and cell-cell interactions within Morton’s neuroma and control nerves at single-cell level
- Extend the applicability of my findings to other human peripheral neuropathies, such as painful diabetic neuropathy
The results of his research will deepen our understanding of the underlying neuro-immune interactions involved in human neuropathic pain, potentially paving the way for the development of macrophage-specific pain treatments within the next decade. In the long run, Dr Chang's career vocation is to translate the promising biomedical discoveries into effective pharmaceutical treatments to manage a variety of neurological disorders.
Key publications
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Journal article
Sandy-Hindmarch OP. et al, (2024), Pain
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Journal article
Shih Y-H. et al, (2020), Nature Communications, 11
Recent publications
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Journal article
Sandy-Hindmarch OP. et al, (2024), Pain
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Investigating neuro-immune interaction in a humanised in vitro microfluidic coculture platform
Poster
Chang P-S. et al, (2024)
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Preprint
Sandy-Hindmarch OP. et al, (2024)
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Immune system: the two-edge sword in our body
Presentation
CHANG P-S., (2021)
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Journal article
Shih Y-H. et al, (2020), Nature Communications, 11
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Cell-based assays to detect cytokine autoantibodies in patients with myasthenia gravis
Poster
Chang P-S. et al, (2019)
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The impact of Exenatide on motor complications in Parkinson’s disease
Poster
Chang P-S. et al, (2017)
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Interaction between hSERF1a/CG17931 and hTau441 in Drosophila model
Poster
Chang P-S. and Sang T-K., (2016)