Puneet Plaha is Consultant Neuro-oncology Surgeon in Oxford with a specialist interest in brain tumours especially Endoscopic minimally invasive surgery and Awake surgery.
Since Aug 2012, he has been a consultant neurosurgeon at the John Radcliffe Oxford University Hospitals. He is Lead of Oxford Neuro oncology MDT since Aug 2012 and Lead for the Thames valley Cancer network for Brain tumours. He is chair of the Neuro oncology section for the Society of British Neurological Surgeons.
He has developed new techniques for minimally invasive endoscopic resection of brain tumours. He has extensive experience in awake brain tumour surgery and has established advanced techniques for awake brain tumour surgery.
He leads the Oxford surgical neuro oncology research group understanding neural networks affected by brain tumours, looking into novel surgical modalities which make brain surgery safer, understanding immunotherapy for brain tumours and novels clinical trials for brain cancer. He is presently Chief Investigator for the multi centre UK NIHR funded FUTURE-GB trial for glioblastoma.
Associate Professor and Consultant NeuroOncology Surgeon.
- MBBS, MS, MD, FRCS, FRCS (SN)
My research interests are focused on using minimally invasive endoscopic techniques to resect brain tumours and advanced brain imaging technologies to develop individually-tailored treatment for brain tumours. I set up and have developed the Awake surgery Brain tumour programme in Oxford and use intraoperative stimulation to understand brain function and “supramaximally” resect brain tumours.
Our research aims are:
- To understand how brain tumours interact with and affect surrounding neural functional networks.
- Plan surgical approaches to the tumour, using non-invasive brain imaging techniques to determine the ideal and maximal resection zone through functional networks.
- Understand how surgical morbidity and hospital length of stay can be reduced using a minimally invasive endoscopic approach to resect brain tumours.
- Identify the transition zone between low grade gliomas and surrounding normal brain in patients undergoing awake surgery using Ultra High definition Intra operative Brain Imaging.
Education and Training
Awake Neurosurgery video: A step-by-step description by Prof Plaha of awake neurosurgery described to the BBC (warning: surgical content). Video kindly provided by BBC Wiltshire on their Facebook site: https://www.facebook.com/BBCWiltshire/videos/632578940244900/
A randomised phase II multicentre study of ipilimumab with temozolomide vs temozolomide alone after surgery and chemoradiotherapy in patients with recently diagnosed glioblastoma: Ipi-Glio.
Mulholland PJ. et al, (2023), Journal of Clinical Oncology, 41, LBA2023 - LBA2023
Diffusion tractography for awake craniotomy: accuracy and factors affecting specificity
Voets NL. et al, (2021), Journal of Neuro-Oncology, 153, 547 - 557
Pitfalls regarding the neurosurgical management of traumatic supra and infratentorial extradural haematomas
Ganau M. et al, (2021), Neurosurgical Review
COVID-legal study: neurosurgeon experience in Britain during the first phase of the COVID-19 pandemic–medico-legal considerations
Finn R. et al, (2021), British Journal of Neurosurgery
Impact of COVID-19 pandemic on surgical neuro-oncology multi-disciplinary team decision making: a national survey (COVID-CNSMDT Study)
Price SJ. et al, (2020), BMJ Open, 10, e040898 - e040898
FUNCTIONALLY GUIDED SUPRAMAXIMAL RESECTION OF IDH-WILDTYPE GLIOBLASTOMAS AND THE EFFECT ON PROGRESSION FREE SURVIVAL
Livermore LJ. et al, (2018), NEURO-ONCOLOGY, 20, 346 - 347
Ma R, Livermore LJ, Plaha P. Fast Track recovery program after Endoscopic and awake intraparenchymal tumor surgery. World Neurosurg 2016.Sep;93:246-52.
Berrington A, Voets NL, Plaha P, Larkin SJ, Mccullagh J, Stacey R, Yildirim M, Schofield CJ, Jezzard P, Cadoux-Hudson T, Ansorge O, Emir U. Tomography 2016. 2(2):94-105.
Emir UE, Larkin SJ, de Pennington N, Voets N, Plaha P, Stacey R, Al-Qahtani K, Mccullagh J, Schofield CJ, Clare S, Jezzard P, Cadoux-Hudson T, Ansorge O. Cancer Research 2016. 76(1):43-49.
Plaha P, Livermore LJ, Voets N, Pereira E, Cudlip S. Minimally invasive endoscopic resection of intraparenchymal brain tumors. World Neurosurg 2014 Jul 29.
Patel NK, Plaha P, Gill SS. Magnetic imaging directed method for functional neurosurgery using implantable guide tubes. Neurosurgery 2007 Nov;61(5 Suppl 2):358-66.
Plaha P, Ben-Shlomo Y, Patel NK, Gill SS. Stimulation of the caudal zona incerta is superior to stimulation of the subthalamic nucleus in improving contralateral parkinsonism. Brain 2006 July; 129(Pt 7): 1732-47
Love S, Plaha P, Patel NK, Hotton GR, Brooks DJ, Gill SS. Glial cell line-derived neurotrophic factor induces neuronal sprouting in human brain. Nature Medicine 2005; 11(7): 703 – 704
Patel NK, Bunnage M, Plaha P, Svendsen CN, Heywood P, Gill SS. Intraputamenal infusion of glial cell line-derived neurotrophic factor in Parkinson’s disease: A two year clinical, cognitive and quality of life outcome study. Ann Neurol. 2005 Feb;57(2):298-302.
Plaha P, Patel NK, Gill SS. Stimulation of the Subthalamic Region for Essential tremor. J Neurosurgery 2004 July; 101: 48-54.