Research groups
Shuaiwei Wang
Postdoctoral Researcher
Biography
After completing his Bachelor’s degree at Jilin University, Shuaiwei Wang studied the molecular regulation of regulatory T cells (Tregs) and autoimmune disease at Institut Pasteur of Shanghai. After obtaining his Master’s degree, he completed his PhD project with Dr. Serge van de Pavert at CIML (Centre d’immunologie de Marseille-Luminy) in France.
During his PhD training, he studied the innate lymphoid cells (ILCs) in ischemic stroke brain. By taking advantage of 3D immunofluorescence on the whole brain, he identified the presence and location of ILCs in the stroke brain lesion. The ILCs numbers at different time points were quantified by flow cytometry, the majority of which were NK cells. By using genetic mouse models, he determined that CXCL12-CXCR4-mediated chemotaxis is indispensable for the infiltration of NK cells in the ischemic brain lesion. He then showed that NK cells is beneficial for the motor recovery from ischemic stroke.
With the aim of further understanding the crosstalk between immune cells and nervous system, he has been working on the immunity in periphery nerve injury at the University of Oxford.
Key publications
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The therapeutic potential of natural killer cells in neuropathic pain
Journal article
Kim HW. et al, (2023), Trends in Neurosciences
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Journal article
Wang S. et al, (2023), Journal of Neuroinflammation
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Journal article
Wang S. and van de Pavert SA., (2022), Frontiers in Immunology, 13
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Journal article
Sirt C. et al, (2022), Nature Communications
Recent publications
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The therapeutic potential of natural killer cells in neuropathic pain
Journal article
Kim HW. et al, (2023), Trends in Neurosciences
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Brain endothelial CXCL12 attracts protective natural killer cells during ischemic stroke
Journal article
Wang S., (2023), Brain endothelial CXCL12 attracts protective natural killer cells during ischemic stroke
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Brain endothelial CXCL12 attracts protective
natural killer cells during ischemic stroke
Journal article
Wang S. et al, (2023), Journal of Neuroinflammation
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Deciphering the heterogeneity of the Lyve1+ perivascular macrophages in the mouse brain
Journal article
Sirt C. et al, (2022), Nature Communications
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Gallic acid induces T-helper-1-like Treg cells and strengthens immune checkpoint blockade efficacy
Journal article
Deng B. et al, (2022), Journal for ImmunoTherapy of Cancer, 10, e004037 - e004037