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Dr Sophie Binks

Clinical Lecturer

Honorary Neurology SpR

Brief biography

After a career in medical communications, I retrained in medicine and graduated with distinction and first in my cohort from Brighton & Sussex Medical School in 2013 (Professor Alasdair Smith prize for best performance in the overall programme), being awarded 18 prizes/scholarships during my medical degree, including three-times recipient of the Dean’s prize for best overall performance (years 1, 2 & 4). I completed a fellowship in autoimmune neurology in Oxford in 2016-2017 and was awarded my DPhil in neuroimmunology from the University of Oxford in 2022. In my current role, I work as a clinician-scientist and early career researcher at NDCN and the John Radcliffe Hospital, Oxford. My research programme focuses on clinical and genetic aspects of autoimmune encephalitis (AE). Significant breakthroughs I have published include human leucocyte antigen genetics (2018) and additional genetic risk loci (2025) in AE associated with antibodies to leucine-rich glioma-inactivated 1 (LGI1-Ab-E) and contactin-associated protein 2 (CASPR2). I have also been at the forefront of describing the impact of fatigue and quality of life outcomes in LGI1-Ab-E (2021 and 2024), and a unique naturally-occurring animal model of LGI1-Ab-E in pet cats (2025). As a thought leader in this field, I am active as an international speaker and educator, including supervision of postgraduate students, patient engagement activities, and professional leadership roles.

Key publications

Distinct HLA associations of LGI1 and CASPR2-antibody diseases

Journal article

Binks S. et al, (2018), Brain, 141, 2263 - 2271

LGI1, CASPR2 and related antibodies: a molecular evolution of the phenotypes

Journal article

Binks SNM. et al, (2018), Journal of Neurology, Neurosurgery & Psychiatry, 89, 526 - 534

Recent publications

Ethical issues in the clinical use of diagnostic technologies for rare causes of psychosis

Journal article

Baum ML. et al, (2026), The British Journal of Psychiatry, 1 - 6

Encephalitis

Journal article

Binks SNM. et al, (2026), The Lancet, 407, 1968 - 1983

The gut microbiome associated with LGI1 ‐antibody encephalitis

Journal article

Gilbert E. et al, (2025), Epilepsia, 66, 4411 - 4424

Distinctive seizure signature in the first video case-control study of a naturally-occurring feline autoimmune encephalitis model

Journal article

Binks SNM. et al, (2025), Brain, Behavior, and Immunity, 126, 289 - 296

Capturing what matters: Patient‐reported LGI1‐ANTibody encephalitis outcome RatiNg scale (LANTERN)

Journal article

Kelly MJ. et al, (2025), Annals of Clinical and Translational Neurology, 12, 821 - 831

More publications