Stuart Peirson

• Sleep homeostasis, habits and habituation.

  Vyazovskiy VV. et al, (2017), Curr Opin Neurobiol, 44, 202 - 211

• Expression and localisation of two-pore domain (K2P) background leak potassium ion channels in the mouse retina.

  Hughes S. et al, (2017), Sci Rep, 7

• Light and the laboratory mouse.

  Peirson SN. et al, (2017), J Neurosci Methods

• Constant Light Desynchronizes Olfactory versus Object and Visuospatial Recognition Memory Performance.

  Tam SK. et al, (2017), J Neurosci, 37, 3555 - 3567

• Modulation of recognition memory performance by light requires both melanopsin and classical photoreceptors.

  Tam SK. et al, (2016), Proc Biol Sci, 283

• Attenuated pupillary light responses and downregulation of opsin expression parallel decline in circadian disruption in two different mouse models of Huntington's disease.

  Ouk K. et al, (2016), Hum Mol Genet, 25

• Stereotypic wheel running decreases cortical activity in mice.

  Fisher SP. et al, (2016), Nat Commun, 7

• Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.

  Potter PK. et al, (2016), Nat Commun, 7

• Reciprocal interactions between circadian clocks and aging.

  Banks G. et al, (2016), Mamm Genome, 27, 332 - 340

• Attenuated pupillary light responses and downregulation of opsin expression parallel decline in circadian disruption in two different mouse models of Huntington's disease.

  Ouk K. et al, (2016), Hum Mol Genet

• Characterisation of light responses in the retina of mice lacking principle components of rod, cone and melanopsin phototransduction signalling pathways.

  Hughes S. et al, (2016), Sci Rep, 6

• Melanopsin Regulates Both Sleep-Promoting and Arousal-Promoting Responses to Light.

  Pilorz V. et al, (2016), PLoS Biol, 14

• Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function.

  Yavari A. et al, (2016), Cell Metab, 23, 821 - 836

• Searching for cognitive enhancement in the Morris water maze: better and worse performance in D-amino acid oxidase knockout (Dao(-/-)) mice.

  Pritchett D. et al, (2016), Eur J Neurosci, 43, 979 - 989

• Signalling by melanopsin (OPN4) expressing photosensitive retinal ganglion cells.

  Hughes S. et al, (2016), Eye (Lond), 30, 247 - 254

• Circadian profiling in two mouse models of lysosomal storage disorders; Niemann Pick type-C and Sandhoff disease.

  Richardson K. et al, (2016), Behav Brain Res, 297, 213 - 223

• COMPASS: Continuous Open Mouse Phenotyping of Activity and Sleep Status.

  Brown LA. et al, (2016), Wellcome Open Res, 1

• Isoforms of Melanopsin Mediate Different Behavioral Responses to Light.

  Jagannath A. et al, (2015), Curr Biol, 25, 2430 - 2434

• Characterisation of a novel ENU-induced spectral tuning mutation in melanopsin

  Rodgers J. et al, (2015), INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56

• Sleep and Circadian Rhythm Disruption in Psychosis

  Peirson SN. and Foster RG., (2015), Circadian Medicine, 271 - 282

• d-amino acid oxidase knockout (Dao(-/-) ) mice show enhanced short-term memory performance and heightened anxiety, but no sleep or circadian rhythm disruption.

  Pritchett D. et al, (2015), Eur J Neurosci, 41, 1167 - 1179

• The hypothalamic photoreceptors regulating seasonal reproduction in birds: a prime role for VA opsin.

  García-Fernández JM. et al, (2015), Front Neuroendocrinol, 37, 13 - 28

• Sleep-like behavior and 24-h rhythm disruption in the Tc1 mouse model of Down syndrome.

  Heise I. et al, (2015), Genes Brain Behav, 14, 209 - 216

• A lack of functional NK1 receptors explains most, but not all, abnormal behaviours of NK1R-/- mice(1).

  Porter AJ. et al, (2015), Genes Brain Behav, 14, 189 - 199

• Using siRNA to define functional interactions between melanopsin and multiple G Protein partners.

  Hughes S. et al, (2015), Cell Mol Life Sci, 72, 165 - 179

• Sleep and circadian rhythm disruption and recognition memory in schizophrenia.

  Tam SK. et al, (2015), Methods Enzymol, 552, 325 - 349

• Photic regulation of clock systems

  Hughes S. et al, (2015), Methods in Enzymology, 552, 125 - 143

• Genetic background influences age-related decline in visual and nonvisual retinal responses, circadian rhythms, and sleep

  Banks G. et al, (2015), Neurobiology of Aging, 36, 380 - 393

• Deletion of Metabotropic Glutamate Receptors 2 and 3 (mGlu2 & mGlu3) in Mice Disrupts Sleep and Wheel-Running Activity, and Increases the Sensitivity of the Circadian System to Light.

  Pritchett D. et al, (2015), PLoS One, 10

• Using siRNA to define functional interactions between melanopsin and multiple G Protein partners

  Hughes S. et al, (2014), Cellular and Molecular Life Sciences, 72, 165 - 179

• Behavioural Characterisation of the D-amino Acid Oxidase (DAO) Knockout Mouse: Heightened Anxiety and Enhanced Short-Term Memory

  Pritchett D. et al, (2014), BIOLOGICAL PSYCHIATRY, 75, 179S - 179S

• The first international workshop on circadian and neurophysiological photoreception, 2013: A physicist’s perspective on the construction of standard units

  Price LLA. and Peirson SN., (2014), Light and Engineering, 22, 24 - 27

• Measuring and using light in the melanopsin age.

  Lucas RJ. et al, (2014), Trends Neurosci, 37, 1 - 9

• Measuring and using light in the melanopsin age

  Lucas RJ. et al, (2014), Trends in Neurosciences, 37, 1 - 9

• Sleep and circadian rhythm disruption in neuropsychiatric illness

  Jagannath A. et al, (2013), Current Opinion in Neurobiology, 23, 888 - 894

• Irradiance encoding in the suprachiasmatic nuclei by rod and cone photoreceptors.

  van Diepen HC. et al, (2013), FASEB J, 27, 4204 - 4212

• Black intraocular lenses: Near infra-red light transmission may risk treatment failure

  Yusuf IH. et al, (2013), British Journal of Ophthalmology, 97, 1353 - 1354

• Nonuniform distribution and spectral tuning of photosensitive retinal ganglion cells of the mouse retina

  Hughes S. et al, (2013), Current Biology, 23, 1696 - 1701

• The CRTC1-SIK1 pathway regulates entrainment of the circadian clock.

  Jagannath A. et al, (2013), Cell, 154, 1100 - 1111

• Near-infrared transillumination photography to detect anterior uveal melanomas through black IOLs.

  Yusuf IH. et al, (2013), Br J Ophthalmol, 97, 943 - 945

• Anterior segment optical coherence tomography in black-on-clear polypseudophakia.

  Yusuf IH. et al, (2013), Acta Ophthalmol, 91, e327 - e328

• The circadian control of sleep.

  Fisher SP. et al, (2013), Handb Exp Pharmacol, 157 - 183

• Sleep and circadian rhythm disruption in social jetlag and mental illness.

  Foster RG. et al, (2013), Prog Mol Biol Transl Sci, 119, 325 - 346

• Evaluating the links between schizophrenia and sleep and circadian rhythm disruption.

  Pritchett D. et al, (2012), J Neural Transm (Vienna), 119, 1061 - 1075

• Ultraviolet light provides a major input to non-image-forming light detection in mice.

  van Oosterhout F. et al, (2012), Curr Biol, 22, 1397 - 1402

• Vertebrate ancient opsin photopigment spectra and the avian photoperiodic response.

  Davies WI. et al, (2012), Biol Lett, 8, 291 - 294

• Inability to perform posterior segment monitoring by scanning laser ophthalmoscopy or optical coherence tomography with some occlusive intraocular lenses in clinical use.

  Yusuf IH. et al, (2012), J Cataract Refract Surg, 38, 513 - 518

• Disrupted circadian rhythms in a mouse model of schizophrenia

  Oliver PL. et al, (2012), Current Biology, 22, 314 - 319

• Rapid assessment of sleep-wake behavior in mice.

  Fisher SP. et al, (2012), J Biol Rhythms, 27, 48 - 58

• Profound defects in pupillary responses to light in TRPM-channel null mice: a role for TRPM channels in non-image-forming photoreception.

  Hughes S. et al, (2012), Eur J Neurosci, 35, 34 - 43

• Melanopsin phototransduction: slowly emerging from the dark.

  Hughes S. et al, (2012), Prog Brain Res, 199, 19 - 40

• Differential expression of melanopsin isoforms Opn4L and Opn4S during postnatal development of the mouse retina.

  Hughes S. et al, (2012), PLoS One, 7

• Occlusive IOLs for intractable diplopia demonstrate a novel near-infrared window of transmission for SLO/OCT imaging and clinical assessment.

  Yusuf IH. et al, (2011), Invest Ophthalmol Vis Sci, 52, 3737 - 3743

• Bad light stops play.

  Peirson SN. and Foster RG., (2011), EMBO Rep, 12

• Photoreceptors and Circadian Clocks

  Peirson SN. and Foster RG., (2010), 669 - 676

• Non-image forming photoreceptors

  Peirson SN. and Foster RG., (2010), Protein Reviews, 12, 105 - 113

• Reply: Blue light-filtering intraocular lenses and scotopic sensitivity

  Cuthbertson FM. et al, (2009), Journal of Cataract and Refractive Surgery, 35

• Blue light-filtering intraocular lenses and scotopic sensitivity REPLY

  Cuthbertson FM. et al, (2009), JOURNAL OF CATARACT AND REFRACTIVE SURGERY, 35, 2032 - 2032

• The evolution of irradiance detection: melanopsin and the non-visual opsins.

  Peirson SN. et al, (2009), Philos Trans R Soc Lond B Biol Sci, 364, 2849 - 2865

• Differential expression of two distinct functional isoforms of melanopsin (Opn4) in the mammalian retina.

  Pires SS. et al, (2009), J Neurosci, 29, 12332 - 12342

• VA opsin-based photoreceptors in the hypothalamus of birds.

  Halford S. et al, (2009), Curr Biol, 19, 1396 - 1402

• Blue light-filtering intraocular lenses: review of potential benefits and side effects.

  Cuthbertson FM. et al, (2009), J Cataract Refract Surg, 35, 1281 - 1297

• A role for Id2 in regulating photic entrainment of the mammalian circadian system.

  Duffield GE. et al, (2009), Curr Biol, 19, 297 - 304

• The effects of rod and cone loss on the photic regulation of locomotor activity and heart rate.

  Thompson S. et al, (2008), Eur J Neurosci, 28, 724 - 729

• Melanopsin: an exciting photopigment.

  Hankins MW. et al, (2008), Trends Neurosci, 31, 27 - 36

• Short-wavelength light sensitivity of circadian, pupillary, and visual awareness in humans lacking an outer retina.

  Zaidi FH. et al, (2007), Curr Biol, 17, 2122 - 2128

• Novel retinal and cone photoreceptor transcripts revealed by human macular expression profiling.

  Hornan DM. et al, (2007), Invest Ophthalmol Vis Sci, 48, 5388 - 5396

• Microarray analysis and functional genomics identify novel components of melanopsin signaling.

  Peirson SN. et al, (2007), Curr Biol, 17, 1363 - 1372

• RNA extraction from mammalian tissues.

  Peirson SN. and Butler JN., (2007), Methods Mol Biol, 362, 315 - 327

• Quantitative polymerase chain reaction.

  Peirson SN. and Butler JN., (2007), Methods Mol Biol, 362, 349 - 362

• Light, photoreceptors, and circadian clocks.

  Foster RG. et al, (2007), Methods Mol Biol, 362, 3 - 28

• Comparison of clock gene expression in SCN, retina, heart, and liver of mice.

  Peirson SN. et al, (2006), Biochem Biophys Res Commun, 351, 800 - 807

• Long-term constant light induces constitutive elevated expression of mPER2 protein in the murine SCN: a molecular basis for Aschoff's rule?

  Muñoz M. et al, (2005), J Biol Rhythms, 20, 3 - 14

• Mammalian photoentrainment: results, methods, and approaches.

  Peirson SN. et al, (2005), Methods Enzymol, 393, 697 - 726

• Expression of the candidate circadian photopigment melanopsin (Opn4) in the mouse retinal pigment epithelium.

  Peirson SN. et al, (2004), Brain Res Mol Brain Res, 123, 132 - 135

• Light-induced c-fos in melanopsin retinal ganglion cells of young and aged rodless/coneless (rd/rd cl) mice.

  Semo M. et al, (2003), Eur J Neurosci, 18, 3007 - 3017

• Experimental validation of novel and conventional approaches to quantitative real-time PCR data analysis.

  Peirson SN. et al, (2003), Nucleic Acids Res, 31

• Multiple photopigments from the Mexican blind cavefish, Astyanax fasciatus: a microspectrophotometric study.

  Parry JW. et al, (2003), Vision Res, 43, 31 - 41

Key Publications

• Constant Light Desynchronizes Olfactory versus Object and Visuospatial Recognition Memory Performance.

  Tam SK. et al, (2017), J Neurosci, 37, 3555 - 3567

• Melanopsin Regulates Both Sleep-Promoting and Arousal-Promoting Responses to Light.

  Pilorz V. et al, (2016), PLoS Biol, 14

• Isoforms of Melanopsin Mediate Different Behavioral Responses to Light.

  Jagannath A. et al, (2015), Curr Biol, 25, 2430 - 2434

• The CRTC1-SIK1 pathway regulates entrainment of the circadian clock.

  Jagannath A. et al, (2013), Cell, 154, 1100 - 1111

• Nonuniform distribution and spectral tuning of photosensitive retinal ganglion cells of the mouse retina

  Hughes S. et al, (2013), Current Biology, 23, 1696 - 1701

Recent Publications

• Sleep homeostasis, habits and habituation.

  Vyazovskiy VV. et al, (2017), Curr Opin Neurobiol, 44, 202 - 211

• Expression and localisation of two-pore domain (K2P) background leak potassium ion channels in the mouse retina.

  Hughes S. et al, (2017), Sci Rep, 7

• Light and the laboratory mouse.

  Peirson SN. et al, (2017), J Neurosci Methods

• Constant Light Desynchronizes Olfactory versus Object and Visuospatial Recognition Memory Performance.

  Tam SK. et al, (2017), J Neurosci, 37, 3555 - 3567

• Modulation of recognition memory performance by light requires both melanopsin and classical photoreceptors.

  Tam SK. et al, (2016), Proc Biol Sci, 283