Contact information
+44 (0)1865 611497
Fax +44 (0)1865 222717
William Clarke
MR Spectroscopist
Advanced, open tools for MR Spectroscopy
My work focusses on developing new methods for magnetic resonance spectroscopy (MRS). Using similar methods to MR imaging (MRI), MRS allows us to quantify the concentrations and chemical kinetics of many neurochemicals in the human brain. Furthermore, by using neurochemicals as endogenous probes we can also map cell-type-specific microstructure. My work seeks to develop new ways of acquiring multi-voxel spectroscopic information to measure chemical dynamics and cellular microstructure across the brain. I have released the open-science MRS analysis tool FSL-MRS and created a range of open-source tools for the MRS community. I am a cofounder of the educational website MRSHub.
Recently I have been awarded a Wellcome Career Development Award. In early 2023 I will be starting a spectroscopy group at WIN, and will be actively recruiting for two post-doctoral researchers working in the areas of MRSI, functional MRS, and diffusion-weighted MRS. Please get in touch in the meantime if you would like more information.
Previously I have worked as spectroscopist in the Physiological Neuroimaging Group and as a post-doctoral researcher in the UK7T Network. The UK7T Network brought together the five 7 tesla MRI capable sites in the UK to develop and promote scanning at this high field strength.
Prior to working in neuroimaging, I completed my doctorate in cardiovascular magnetic resonance spectroscopy. This work focused on the high-energy phosphorus metabolism of the human myocardium.
Key publications
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FSL‐MRS: An end‐to‐end spectroscopy analysis package
Journal article
Clarke WT. et al, (2020), Magnetic Resonance in Medicine
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NIfTI-MRS: A standard data format for magnetic resonance spectroscopy
Journal article
CLARKE W. et al, (2022), Magnetic Resonance in Medicine
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Creatine kinase rate constant in the human heart measured with 3D-localization at 7 tesla
Journal article
Clarke WT. et al, (2017), Magnetic Resonance in Medicine, 78, 20 - 32
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Multi-Site Harmonization of 7 Tesla MRI Neuroimaging Protocols
Journal article
CLARKE W. et al, (2019), NeuroImage
Recent publications
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Retained Metabolic Flexibility of the Failing Human Heart
Journal article
Watson WD. et al, (2023), Circulation
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Repeated unilateral handgrip contractions alter functional connectivity and improve contralateral limb response times.
Journal article
Andrushko JW. et al, (2023), Sci Rep, 13
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Cerebellar GABA Change during Visuomotor Adaptation Relates to Adaptation Performance and Cerebellar Network Connectivity: A Magnetic Resonance Spectroscopic Imaging Study
Journal article
Nettekoven C. et al, (2022), Journal of Neuroscience, 42, 7721 - 7732
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tDCS induced GABA change is associated with the simulated electric field in M1, an effect mediated by grey matter volume in the MRS voxel.
Journal article
Nandi T. et al, (2022), Brain Stimul
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2½-minute 3D 7T 31P-MRSI of the human heart using concentric rings (CRT)
Journal article
CLARKE W. et al, (2022), NMR in Biomedicine