Xin You Tai
Wellcome Trust Academic Clinical Fellow & DPhil student
- Neurology Specialist Trainee
- Academic Clinical Fellow
- DPhil Biomedical and Clinical Sciences student
Hippocampal dysfunction across neurodegenerative conditions
My research focus is examining cognitive, and particularly hippocampal, dysfunction across different neurological conditions and ageing. I am interested in the electrical disruption as a mechanism of memory problems and network changes in temporal lobe epilepsy and cerebrovascular disease and how this relates to ageing and other neurodegenerative conditions. I am also interested in molecular pathways, such as tau-related processes, in conditions such as epilepsy. I am also looking to better understand how memory works in healthy individuals including how we shift information from short term to long term memory.
I use neurophysiology and neuroimaging along with behavioural testing to examine cognitive function. My research also uses large population datasets to help answer these questions around cognitive function and dementia. This involves using statistical modelling of data and applying machine learning towards disease prediction.
My other interests include medical education and science communication. I teach regularly, supervise students and am an examiner on the Oxford University medical school board of examiners. I am also the editor of the Brain podcast for the neuroscience journal Brain.
Impact of sleep duration on executive function and brain structure
Tai XY. et al, (2022), Communications Biology
Impact of the COVID-19 pandemic on people with epilepsy: Findings from the Brazilian arm of the COV-E study.
Andraus M. et al, (2021), Epilepsy Behav, 123
Review: Neurodegenerative processes in temporal lobe epilepsy with hippocampal sclerosis: Clinical, pathological and neuroimaging evidence
Tai XY. et al, (2018), Neuropathology and Applied Neurobiology, 44, 70 - 90
Deconstructing Fahr's disease/syndrome of brain calcification in the era of new genes
Batla A. et al, (2017), Parkinsonism & Related Disorders, 37, 1 - 10
Hyperphosphorylated tau in patients with refractory epilepsy correlates with cognitive decline: a study of temporal lobe resections
Tai XY. et al, (2016), Brain, 139, 2441 - 2455