Xin You Tai
Wellcome Trust Academic Clinical Fellow & DPhil student
- Neurology Specialist Trainee
- DPhil Biomedical and Clinical Sciences
Hippocampal dysfunction across neurodegenerative conditions
My research focus is examining cognitive, and particularly hippocampal, dysfunction across different neurological conditions and ageing. I am interested in the electrical disruption as a mechanism of memory problems and network changes in temporal lobe epilepsy and cerebrovascular disease and how this relates to ageing and other neurodegenerative conditions. I am also looking to better understand how memory works in healthy individuals including how we shift information from short term to long term memory.
I use neurophysiology and neuroimaging along with behavioural testing to examine cognitive function. The Computational Neurology group is also interested in people with Parkinson's disease and focal brain lesions.
Review: Neurodegenerative processes in temporal lobe epilepsy with hippocampal sclerosis: Clinical, pathological and neuroimaging evidence
Tai XY. et al, (2018), Neuropathology and Applied Neurobiology, 44, 70 - 90
Deconstructing Fahr's disease/syndrome of brain calcification in the era of new genes
Batla A. et al, (2017), Parkinsonism & Related Disorders, 37, 1 - 10
Hyperphosphorylated tau in patients with refractory epilepsy correlates with cognitive decline: a study of temporal lobe resections
Tai XY. et al, (2016), Brain, 139, 2441 - 2455
Fahr's disease: current perspectives
Batla A. and Tai XY., (2015), Orphan Drugs: Research and Reviews, 43 - 43