Georgios Baskozos
MSc, PhD
Associate Professor
Bio-informatician
My main research interest lies in the bioinformatics of neuropathic pain including genetics, transcriptomics, functional genomics and predictive modelling. I have a particular interest in the transcriptional analysis of peripheral nerve injury both in humans and animal models of pain and I have developed a customised computational pipeline for the identification of novel long non-coding RNAs and gene model reconstruction using RNA-sequencing.
In addition, I have extensive experience in designing and implementing computational workflows for the analysis of Whole Genome and Exome Sequencing data working closely with experimental biologists and medical doctors.
I have also a keen interest in data analysis of large scale clinical datasets with heterogenous variables using exploratory data analysis, statistical learning and predictive modelling techniques. I am currently applying machine learning methods and developing computational workflows as the only directly appointed researcher for the Diabetes UK Project Grant 19/0005984 “Using machine learning to predict painful diabetic neuropathy”. I am also funded as a researcher co-investigator at the "Partnership for Assessment and Investigation of Neuropathic Pain: Studies Tracking Outcomes, Risks and Mechanisms (PAINSTORM)" UKRI - Versus Arthritis APDP grant.
Finally, I support my colleagues, being part of David Bennett’s group, with statistics, hypothesis testing and advice on experimental design.
Key publications
SLC45A4 is a pain gene encoding a neuronal polyamine transporter
Journal article
Middleton SJ. et al, (2025), Nature, 646, 404 - 412
The local molecular signature of human peripheral neuropathic pain
Journal article
Sandy-Hindmarch OP. et al, (2025), Pain, 166, 1143 - 1156
Predicting ‘pain genes’: multi-modal data integration using probabilistic classifiers and interaction networks
Journal article
Zhao N. et al, (2024), Bioinformatics Advances, 4
Deep RNA-seq of male and female murine sensory neuron subtypes after nerve injury
Journal article
Barry AM. et al, (2023), Pain, 164, 2196 - 2215
Epidemiology of neuropathic pain: an analysis of prevalence and associated factors in UK Biobank
Journal article
Baskozos G. et al, (2023), PAIN Reports, 8, e1066 - e1066
Classification of painful or painless diabetic peripheral neuropathy and identification of the most powerful predictors using machine learning models in large cross-sectional cohorts
Journal article
Baskozos G. et al, (2022), BMC Medical Informatics and Decision Making, 22
Investigating genotype-phenotype relationship of extreme neuropathic pain disorders in a national cohort: ’NIHR Bioresources Rare Disease – Neuropathic Pain Disorders’
Journal article
THEMISTOCLEOUS A. et al, (2022), Brain Communications
The effectiveness of Non-pharmaceutical interventions in reducing the COVID-19 contagion in the UK, an observational and modelling study
Journal article
Galanis G. et al, (2021), PLOS ONE, 16, e0260364 - e0260364
Molecular and cellular correlates of human nerve regeneration: ADCYAP1/PACAP enhance nerve outgrowth
Journal article
Baskozos G. et al, (2020), Brain, 143, 2009 - 2026
Comprehensive analysis of long noncoding RNA expression in dorsal root ganglion reveals cell-type specificity and dysregulation after nerve injury
Journal article
Baskozos G. et al, (2019), Pain, 160, 463 - 485
Recent publications
Sex-specific molecular signatures in persistent pain after whiplash injury: an exploratory analysis
Journal article
Fundaun J. et al, (2026), PAIN Reports
Physical activity decreases the likelihood of peripheral neuropathy in persons with diabetes.
Journal article
Reynolds EL. et al, (2026), J Neurol Neurosurg Psychiatry, 97, 464 - 468
NKG2D receptor ligands are cell surface biomarkers for injured murine and human nociceptive sensory neurons
Journal article
Wang S. et al, (2025), Journal of Neuroinflammation, 23
Plasma periaxin is a biomarker of peripheral nerve demyelination
Journal article
Bellanti R. et al, (2025), Brain, 148, 4448 - 4460
The Association Between Detailed Obesity Measurements and Peripheral Neuropathy in Persons With Diabetes.
Journal article
Reynolds EL. et al, (2025), Eur J Neurol, 32
Transcriptomic evidence linking adaptive immunity and the IGF-1 pathway in carpal tunnel syndrome
Preprint
De Pace AL. et al, (2025)
SLC45A4 is a pain gene encoding a neuronal polyamine transporter
Journal article
Middleton SJ. et al, (2025), Nature, 646, 404 - 412
NKG2D receptor ligands are cell surface biomarkers for injured murine and human nociceptive sensory neurons
Preprint
Wang S. et al, (2025)
The local molecular signature of human peripheral neuropathic pain
Journal article
Sandy-Hindmarch OP. et al, (2025), Pain, 166, 1143 - 1156
Serum Neurofilament Light Chain and Structural and Functional Nerve Fiber Loss in Painful and Painless Diabetic Polyneuropathy.
Journal article
Määttä LL. et al, (2025), Diabetes Res Clin Pract, 223
The presence and prognosis of nerve pathology following whiplash injury: a prospective cohort study
Journal article
Fundaun J. et al, (2025), Brain
Implication of Rare SARM1 and NMNAT2 Variants in Inherited and Acquired Neuropathy
Conference paper
Morsy H. et al, (2025), JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 30, 51 - 52
The Association Between Detailed Obesity Measurements and Peripheral Neuropathy in Persons With Diabetes
Conference paper
Reynolds EL. et al, (2025), EUROPEAN JOURNAL OF NEUROLOGY, 32
Multi-Omic Integration on Diabetic Peripheral Neuropathy Reveals Distinct Pathways Associated With the Presence and Intensity of Neuropathic Pain
Conference paper
Baskozos G. et al, (2025), JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 30, 245 - 246
Identification of SLC45A4 as a Pain Gene Encoding a Neuronal Polyamine Transporter
Conference paper
Middleton S. et al, (2025), JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 30, 99 - 99
Kcnt2 is a Potential Therapeutic Target For Neuropathic Pain
Conference paper
Bolivar S. et al, (2025), JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 30, 246 - 246
MEAanalysis: an open-source R package for downstream visualization of AxIS navigator multi-electrode array burst data at the single-electrode level
Journal article
Gordon EA. et al, (2024), Bioinformatics Advances, 5
What is associated with painful polyneuropathy? A cross-sectional analysis of symptoms and signs in patients with painful and painless polyneuropathy.
Journal article
Gierthmühlen J. et al, (2024), Pain, 165, 2888 - 2899
Correction: Development and external validation of multivariable risk models to predict incident and resolved neuropathic pain: a DOLORisk Dundee study.
Journal article
Hébert HL. et al, (2024), J Neurol, 271, 7652 - 7653
Prevalence of weakness and factors mediating discrepancy between reported and observed leg weakness in people with sciatica
Journal article
Dove L. et al, (2024), European Spine Journal, 33, 4229 - 4234
Genetic associations of neuropathic pain and sensory profile in a deeply phenotyped neuropathy cohort
Journal article
BASKOZOS G. et al, (2024), Pain
Identification of SLC45A4 as a pain gene encoding a neuronal polyamine transporter
Preprint
Middleton SJ. et al, (2024)
Reliability of a clinical sensory test battery in patients with spine‐related leg and arm pain
Journal article
Bender C. et al, (2024), European Journal of Pain, 28, 1366 - 1377
Mechanisms of neurodynamic treatments (MONET): a protocol for a mechanistic, randomised, single-blind controlled trial in patients with carpal tunnel syndrome
Journal article
E. S-S. et al, (2024), BMC Musculoskeletal Disorders, 25
Predicting “pain genes”: multi-modal data integration using probabilistic classifiers and interaction networks
Preprint
Zhao N. et al, (2024)
Predicting ‘pain genes’: multi-modal data integration using probabilistic classifiers and interaction networks
Journal article
Zhao N. et al, (2024), Bioinformatics Advances, 4
The Molecular Signature of Neuropathic Pain in a Human Model System
Preprint
Sandy-Hindmarch OP. et al, (2024)
GENOME-WIDE ASSOCIATION STUDY OF DIABETIC NEUROPATHY IN UK BIOBANK
Conference paper
Morsy H. et al, (2024), JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 29, S60 - S61
GENETIC RISK FACTORS AND CORRELATIONS OF NEUROPATHIC AND CHRONIC PAIN WITH PSYCHIATRIC DISORDERS: INSIGHTS FROM THE DOLORISK STUDY AND UK BIOBANK
Journal article
Li W. et al, (2024), EUROPEAN NEUROPSYCHOPHARMACOLOGY, 87, 214 - 214
Utilising clinical parameters to improve the selection of nerve biopsy candidates
Journal article
Kopanidis P. et al, (2023), Internal Medicine Journal, 53, 2224 - 2230
