CRISPR Workshop
DATE AND VENUE
Tuesday 1 July 2025, 1.30-6.30pm, TS Eliot Theatre, Merton College, Oxford.
Sponsored by the NIHR Oxford Biomedical Research Centre's Gene and Cell Therapy theme.
REGISTRATION
This event is open to Oxford University research staff and graduate students. Online registration is open until Friday 20 June 2025 via this registration form. Note that online registration may close before this date if all seats are filled. (An Oxford University Single Sign-On is required for access to the registration form.)
PROGRAMME
| 13.15 | REGISTRATION | |
| 14.00 | Robert MacLaren, Theme Leader for Gene and Cell Therapy, NIHR Oxford Biomedical Research Centre | Welcoming address |
| 14.05 | SESSION 1: CRISPR-based gene editing, activation, silencing and epigenetic applications (Chair: Ahmed Salman) | |
| Ahmed Salman, Postdoctoral Research Scientist, Nuffield Department of Clinical Neurosciences | Possibility of allele-specific targeting of AMD-risk SNPs with CRISPR: current limitations, challenges and future applications | |
| Akbar Shahid, Postdoctoral Research Scientist, Ludwig Institute for Cancer Research | An inducible haematopoietic stem cell (HSC) model to understand leukaemic transformation | |
| Ana Aragón-González, Postdoctoral Research Scientist, Nuffield Department of Clinical Neurosciences | Inducible CRISPRi gene silencing in iPSC-derived dopaminergic neurons from Parkinson’s patients | |
| Elena Tybulewicz, DPhil Student, Radcliffe Department of Medicine | Gene editing strategies for dominant-negative mutations in SFTPC | |
| Sophia Bellingrath, DPhil Student, Nuffield Department of Clinical Neurosciences | Investigation of an RNA base editor to edit a nonsense mutation in a novel Crb1 mouse model | |
| Christian Babbs, Head of Genome Engineering, Genome Engineering & Transgenics Facility, MRC Weatherall Institute of Molecular Medicine | Implementing AAV/RNP editing in 1-cell mouse embryos | |
| Joey Riepsaame, Head of Genome Engineering, Genome Engineering Oxford (GEO) Facility, Sir William Dunn School of Pathology | CELLect 2.0: expanding the scope of prime editing and novel Cas9 variants for enhanced gene editing precision | |
| 15.30 | COFFEE BREAK | |
| 16.00 | SESSION 2: CRISPR-based screening and diagnostics, delivery strategies for CRISPR systems and clinical translation of CRISPR technologies (Chair: Benjamin Ng) | |
| Benjamin Ng, DPhil Student, Nuffield Department of Clinical Neurosciences |
AAV delivery strategies for large CRISPR constructs | |
|
Sam Washer, Postdoctoral Research Scientist, Centre for Medicines Discovery |
CRISPR screening in iPSC derived microglia for regulators of phagocytosis | |
| Celine Santiago, Postdoctoral Research Scientist, Radcliffe Department of Medicine | A CRISPR-based bi-allelic iPSC reporter line for modelling TTNtv-related dilated cardiomyopathy | |
| Shahzaib Tariq, DPhil Student, Radcliffe Department of Medicine | Hitching a ride with a humanised retroelement | |
| Christina Yan, DPhil Student, Nuffield Department of Women’s & Reproductive Health | Engineered extracellular vesicles (EVs) for efficient delivery of CRISPR-Cas9 systems | |
| James Davies, Associate Professor of Genomics, MRC Weatherall Institute of Molecular Medicine | New indications for genome editing of haematopoietic stem cells | |
| 17.15 | DRINKS AND CANAPÉS |