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DATE AND VENUE

Thursday 4 July 2024, 1.30-6.30pm, TS Eliot Theatre, Merton College, Oxford.

Sponsored by the NIHR Oxford Biomedical Research Centre's Gene and Cell Therapy theme.

REGISTRATION

This event is open to Oxford University research staff and graduate students. Online registration is open until Friday 21 June 2024 via this registration form. Note that online registration may close before this date if all seats are filled. (An Oxford University Single Sign-On is required for access to the registration form.)

PROGRAMME

13.15 REGISTRATION
14.00 Robert MacLaren, Theme Leader for Gene and Cell Therapy, NIHR Oxford Biomedical Research Centre Welcoming address
14.05 SESSION 1: CRISPR-based gene editing, activation, silencing and epigenetic applications (Chair: Sophia Bellingrath)
Sophia Bellingrath, DPhil Student, Nuffield Department of Clinical Neurosciences Assessment and correction of two splice site mutations in CRB1 with RNA editing
Sam Jones, DPhil Student, Radcliffe Department of Medicine Base editing for the allele-specific silencing of dominant negative genetic variants in inherited cardiomyopathies
Celia Sourd, Postdoctoral Research Scientist, Nuffield Department of Clinical Neurosciences Gene editing approaches for myotubular myopathy
Benjamin Ng, DPhil Student, Nuffield Department of Clinical Neurosciences Applications of CRISPR activation in the eye
Bora Ozcan, Research Assistant, Radcliffe Department of Medicine Epigenetic silencing of therapeutic targets in primary T cells
Weijiao Zhang, Postdoctoral Research Scientist, Radcliffe Department of Medicine Developing a genome editing approach for immune-mediated diseases
Georgie Fisher, Research Assistant, Genome Engineering Oxford, Sir William Dunn School of Pathology A novel co-selection system to enrich for prime editing events in mammalian cells
15.30 COFFEE BREAK
16.00 SESSION 2: Delivery strategies for CRISPR systems and clinical translation of CRISPR technologies (Chair: Connie Han)
Connie Han, DPhil Student, Nuffield Department of Clinical Neurosciences
Chemically modified CRISPR sgRNA for non-viral delivery
Filipa Simões, Group Leader, Department of Physiology, Anatomy and Genetics Next-Gen cardiac regeneration: Cas9-mediated gene editing via electroporation of injured zebrafish hearts
Jakob Hansen Haldrup, Postdoctoral Research Scientist, Radcliffe Department of Medicine Stealth delivery of gene editing systems by repurposing human proteins and fusogens
Dhanu Gupta, Postdoctoral Research Scientist, Department of Paediatrics Engineered extracellular vesicles for gene editing applications
Yavor Bozhilov, Postdoctoral Research Scientist, Radcliffe Department of Medicine Developing a stable human haematopoietic stem cell culture system for CRISPR/Cas9-based genome editing
Stephan Sanders, Professor of Neurogenetics, Department of Paediatrics Facilitating reprogramming of genome editing therapies at scale
17.15 DRINKS AND CANAPÉS