Key Publications
A list of key publications by the PAIN Group at FMRIB.
Bantick SJ, Wise RG, Ploghaus A, Clare S, Smith SM, Tracey I. Imaging how
attention modulates pain in humans using functional MRI. Brain. 2002 Feb;125(Pt
2):310-9. PubMed PMID: 11844731.
Berna C, Leknes S, Holmes EA, Edwards RR, Goodwin GM, Tracey I. Induction of
depressed mood disrupts emotion regulation neurocircuitry and enhances pain
unpleasantness. Biol Psychiatry. 2010 Jun 1;67(11):1083-90. doi:
10.1016/j.biopsych.2010.01.014. Epub 2010 Mar 29. PubMed PMID: 20303069.
Bingel U, Wanigasekera V, Wiech K, Ni Mhuircheartaigh R, Lee MC, Ploner M,
Tracey I. The effect of treatment expectation on drug efficacy: imaging the
analgesic benefit of the opioid remifentanil. Sci Transl Med. 2011 Feb
16;3(70):70ra14. doi: 10.1126/scitranslmed.3001244. PubMed PMID: 21325618.
Brodersen KH, Wiech K, Lomakina EI, Lin CS, Buhmann JM, Bingel U, Ploner M,
Stephan KE, Tracey I. Decoding the perception of pain from fMRI using
multivariate pattern analysis. Neuroimage. 2012 Nov 15;63(3):1162-70. doi:
10.1016/j.neuroimage.2012.08.035. Epub 2012 Aug 18. PubMed PMID: 22922369; PubMed
Brooks JC, Kong Y, Lee MC, Warnaby CE, Wanigasekera V, Jenkinson M, Tracey I.
Stimulus site and modality dependence of functional activity within the human
spinal cord. J Neurosci. 2012 May 2;32(18):6231-9. doi:
10.1523/JNEUROSCI.2543-11.2012. PubMed PMID: 22553029.
Brooks JC, Zambreanu L, Godinez A, Craig AD, Tracey I. Somatotopic
organisation of the human insula to painful heat studied with high resolution
functional imaging. Neuroimage. 2005 Aug 1;27(1):201-9. PubMed PMID: 15921935.
Denk F, McMahon SB, Tracey I. Pain vulnerability: a neurobiological
perspective. Nat Neurosci. 2014 Feb;17(2):192-200. doi: 10.1038/nn.3628. Epub
2014 Jan 28. Review. PubMed PMID: 24473267.
Gwilym SE, Filippini N, Douaud G, Carr AJ, Tracey I. Thalamic atrophy
associated with painful osteoarthritis of the hip is reversible after
arthroplasty: a longitudinal voxel-based morphometric study. Arthritis Rheum.
2010 Oct;62(10):2930-40. doi: 10.1002/art.27585. PubMed PMID: 20518076.
Iannetti GD, Zambreanu L, Wise RG, Buchanan TJ, Huggins JP, Smart TS, Vennart
W, Tracey I. Pharmacological modulation of pain-related brain activity during
normal and central sensitization states in humans. Proc Natl Acad Sci U S A. 2005
Dec 13;102(50):18195-200. Epub 2005 Dec 5. PubMed PMID: 16330766; PubMed Central
Kong Y, Eippert F, Beckmann CF, Andersson J, Finsterbusch J, Büchel C, Tracey
I, Brooks JC. Intrinsically organized resting state networks in the human spinal
cord. Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):18067-72. doi:
10.1073/pnas.1414293111. Epub 2014 Dec 3. PubMed PMID: 25472845; PubMed Central
Lee MC, Zambreanu L, Menon DK, Tracey I. Identifying brain activity
specifically related to the maintenance and perceptual consequence of central
sensitization in humans. J Neurosci. 2008 Nov 5;28(45):11642-9. doi:
10.1523/JNEUROSCI.2638-08.2008. PubMed PMID: 18987200.
Leknes S, Berna C, Lee MC, Snyder GD, Biele G, Tracey I. The importance of
context: when relative relief renders pain pleasant. Pain. 2013
Mar;154(3):402-10. doi: 10.1016/j.pain.2012.11.018. Epub 2012 Dec 13. PubMed
PMID: 23352758; PubMed Central PMCID: PMC3590449.
Makin TR, Scholz J, Filippini N, Henderson Slater D, Tracey I, Johansen-Berg
H. Phantom pain is associated with preserved structure and function in the former
hand area. Nat Commun. 2013;4:1570. doi: 10.1038/ncomms2571. PubMed PMID:
23463013; PubMed Central PMCID: PMC3615341.
Mezue M, Segerdahl AR, Okell TW, Chappell MA, Kelly ME, Tracey I. Optimization
and reliability of multiple postlabeling delay pseudo-continuous arterial spin
labeling during rest and stimulus-induced functional task activation. J Cereb
Blood Flow Metab. 2014 Dec;34(12):1919-27. doi: 10.1038/jcbfm.2014.163. Epub 2014
Oct 1. PubMed PMID: 25269517; PubMed Central PMCID: PMC4269746.
Mhuircheartaigh RN, Rosenorn-Lanng D, Wise R, Jbabdi S, Rogers R, Tracey I.
Cortical and subcortical connectivity changes during decreasing levels of
consciousness in humans: a functional magnetic resonance imaging study using
propofol. J Neurosci. 2010 Jul 7;30(27):9095-102. doi:
10.1523/JNEUROSCI.5516-09.2010. PubMed PMID: 20610743.
Ní Mhuircheartaigh R, Warnaby C, Rogers R, Jbabdi S, Tracey I. Slow-wave
activity saturation and thalamocortical isolation during propofol anesthesia in
humans. Sci Transl Med. 2013 Oct 23;5(208):208ra148. doi:
10.1126/scitranslmed.3006007. PubMed PMID: 24154602.
Ploghaus A, Narain C, Beckmann CF, Clare S, Bantick S, Wise R, Matthews PM,
Rawlins JN, Tracey I. Exacerbation of pain by anxiety is associated with activity
in a hippocampal network. J Neurosci. 2001 Dec 15;21(24):9896-903. PubMed PMID:
Ploghaus A, Tracey I, Clare S, Gati JS, Rawlins JN, Matthews PM. Learning
about pain: the neural substrate of the prediction error for aversive events.
Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9281-6. PubMed PMID: 10908676; PubMed
Ploghaus A, Tracey I, Gati JS, Clare S, Menon RS, Matthews PM, Rawlins JN.
Dissociating pain from its anticipation in the human brain. Science. 1999 Jun
18;284(5422):1979-81. PubMed PMID: 10373114.
Ploner M, Lee MC, Wiech K, Bingel U, Tracey I. Prestimulus functional
connectivity determines pain perception in humans. Proc Natl Acad Sci U S A. 2010
Jan 5;107(1):355-60. doi: 10.1073/pnas.0906186106. Epub 2009 Nov 30. PubMed PMID:
19948949; PubMed Central PMCID: PMC2806712.
Rogers R, Wise RG, Painter DJ, Longe SE, Tracey I. An investigation to
dissociate the analgesic and anesthetic properties of ketamine using functional
magnetic resonance imaging. Anesthesiology. 2004 Feb;100(2):292-301. PubMed PMID:
Tracey I. Getting the pain you expect: mechanisms of placebo, nocebo and
reappraisal effects in humans. Nat Med. 2010 Nov;16(11):1277-83. doi:
10.1038/nm.2229. Epub 2010 Oct 14. PubMed PMID: 20948533.
Tracey I, Ploghaus A, Gati JS, Clare S, Smith S, Menon RS, Matthews PM.
Imaging attentional modulation of pain in the periaqueductal gray in humans. J
Neurosci. 2002 Apr 1;22(7):2748-52. PubMed PMID: 11923440.
Wanigasekera V, Lee MC, Rogers R, Kong Y, Leknes S, Andersson J, Tracey I.
Baseline reward circuitry activity and trait reward responsiveness predict
expression of opioid analgesia in healthy subjects. Proc Natl Acad Sci U S A.
2012 Oct 23;109(43):17705-10. doi: 10.1073/pnas.1120201109. Epub 2012 Oct 8.
PubMed PMID: 23045652; PubMed Central PMCID: PMC3491480.
Wiech K, Lin CS, Brodersen KH, Bingel U, Ploner M, Tracey I. Anterior insula
integrates information about salience into perceptual decisions about pain. J
Neurosci. 2010 Dec 1;30(48):16324-31. doi: 10.1523/JNEUROSCI.2087-10.2010. PubMed
Wiech K, Jbabdi S, Lin CS, Andersson J, Tracey I. Differential structural and
resting state connectivity between insular subdivisions and other pain-related
brain regions. Pain. 2014 Oct;155(10):2047-55. doi: 10.1016/j.pain.2014.07.009.
Epub 2014 Jul 15. PubMed PMID: 25047781; PubMed Central PMCID: PMC4220010.
Wiech K, Vandekerckhove J, Zaman J, Tuerlinckx F, Vlaeyen JW, Tracey I.
Influence of prior information on pain involves biased perceptual
decision-making. Curr Biol. 2014 Aug 4;24(15):R679-81. doi:
10.1016/j.cub.2014.06.022. PubMed PMID: 25093555; PubMed Central PMCID:
Wise RG, Williams P, Tracey I. Using fMRI to quantify the time dependence of
remifentanil analgesia in the human brain. Neuropsychopharmacology. 2004
Mar;29(3):626-35. PubMed PMID: 14679387.
Zambreanu L, Wise RG, Brooks JC, Iannetti GD, Tracey I. A role for the
brainstem in central sensitisation in humans. Evidence from functional magnetic
resonance imaging. Pain. 2005 Apr;114(3):397-407. PubMed PMID: 15777865.