Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

The Xue Lab is a translational research group investigating the mechanisms of retinal inflammation and degeneration in the context of age-related macular degeneration (AMD), uveitis and retinal gene therapy. Our aim is to translate improved understanding of disease mechanisms into clinical trials for patients with retinal diseases, and ultimately new therapies to prevent sight loss.

DNA and researcher looking into eye equipment in the lab

Age-related macular degeneration (AMD) is the leading cause of sight loss affecting one in eight individuals over the age of 60, yet there is currently no treatment for the majority of macular degeneration. Uveitis is another major cause of severe visual impairment in the working age. Current therapy involves systemic immunosuppression which is associated with potentially severe adverse effects and loss of quality of life. Retinal inflammation and immunity play key roles in the pathogenesis of both conditions. In addition, retinal inflammation is a major limiting factor on the clinical efficacy of gene therapies for inherited retinal diseases.


  • Investigate the mechanisms of retinal inflammation and degeneration using disease models
  • Develop new treatments to control intraocular inflammation and prevent sight loss from age-related macular degeneration and uveitis
  • Improve the safety and efficacy of retinal surgery and gene therapy
  • Translate laboratory and pre-clinical findings into clinical trials


Clinical Ophthalmology Research Group

Oxford Eye Research Group

Calliope Dendrou, Kennedy Institute of Rheumatology

Christopher Buckley, Kennedy Institute of Rheumatology


Laurel Chandler, DPhil (Merton College Oxford)

Ayesha Musa, FHS student 2020 (Jesus College Oxford)

James Aylward, BM-BCh (St Hilda's College Oxford)

Dun Jack Fu, BM-BCh PhD (St Hugh's College Oxford)

Olivia Parham, FHS student 2016 (New College Oxford)

Howell Fu, FHS student 2015 (Exeter College Oxford)


Fight for Sight logo

Selected publications