Contact information
Colleges
BIOGRAPHY
Kanmin Xue, MB BChir PhD FRCOphth, is a Wellcome Trust clinician scientist fellow at the University of Oxford and Honorary Consultant Vitreoretinal Surgeon at the Oxford Eye Hospital. He previously held the role of National Institute for Health Research (NIHR) Academic Clinical Lecturer in Oxford between 2014 and 2018, conducting laboratory and clinical research into gene therapy for inherited retinal diseases, robotic eye surgery and artificial retinal implant with Professor Robert MacLaren. He has completed the UK specialist training in ophthalmology and a vitreoretinal fellowship at the Royal Victorian Eye and Ear Hospital in Melbourne, Australia. He previously conducted PhD research at the MRC Laboratory of Molecular Biology in Cambridge into how DNA editing brings about antibody class switching, underwent clinical training at Trinity College Cambridge, and pre-clinical training at Brasenose College Oxford, where he was awarded Martin Wronker Prize for the top First Class in Medicine.
AWARDS
Ruskell Medal 2019
Ian Fraser Cup 2017
Luigi Barca Award 2017
Martin Wronker Prize in Medicine 2003
Kanmin Xue
MA MB BChir PhD FRCOphth
Wellcome Trust Clinical Research Career Development Fellow
- Honorary Consultant Ophthalmologist & Vitreoretinal Surgeon, Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust
- Medical Research Fellow, Corpus Christi College, Oxford
Research
The retina is an accessible part of the central nervous system and an ideal organ for studying neurodegeneration and assessing novel gene therapies. Kanmin leads the Retinal Disease and Repair Group, which is currently focused on investigating the mechanisms of retinal degeneration and inflammation in the context of age-related macular degeneration (AMD) and uveitis. Improved understanding of these diseases supports the development of novel therapeutic approaches, including viral and non-viral vector-mediated gene delivery, gene editing, and antisense oligonucleotide therapies. Clinical translation is aided by a multi-disciplinary approach, involving patient cohort studies, interventional clinical trials, and application of artificial intelligence (AI).
Team members
Joel Quinn, DPhil candidate & MRC scholar (Merton College Oxford)
Molly John, Research Assistant
Monica Hu, DPhil candidate & Clarendon scholar (Merton College Oxford)
Past students
Laurel Chandler, DPhil (Merton College Oxford)
- Thomas Willis Poster Prize 2019
- Oxford-Bristol-Cardiff-Southampton Alliance in Vision Research Best Poster Prize 2017
Ayesha Musa, FHS student 2020 (Jesus College Oxford)
James Aylward, BM-BCh (St Hilda's College Oxford)
Dun Jack Fu, BM-BCh PhD (St Hugh's College Oxford)
Olivia Parham, FHS student 2016 (New College Oxford)
Howell Fu, FHS student 2015 (Exeter College Oxford)
Research groups
Collaborators
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Robert MacLaren
Professor of Ophthalmology
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Jasmina Kapetanovic
MRC Clinician Scientist and Consultant Vitreo-Retinal Surgeon
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Samantha de Silva
Consultant Ophthalmologist
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Dominik Fischer
Professor of Ophthalmology
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Michelle McClements
Senior Postdoctoral Research Scientist
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Amandeep Josan
Specialist Optometrist
Key publications
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Journal article
Chandler LC. et al, (2021), Molecular Therapy - Methods & Clinical Development, 22, 52 - 65
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Journal article
Quinn J. et al, (2021), Human Gene Therapy, 32, 247 - 259
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Journal article
Xue K. and MacLaren RE., (2020), Expert Opin Investig Drugs, 29, 1163 - 1170
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Journal article
Cehajic-Kapetanovic J. et al, (2020), Nature Medicine, 26, 354 - 359
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Journal article
Chandler LC. et al, (2019), Molecular Therapy - Methods & Clinical Development, 14, 77 - 89
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Journal article
Xue K. et al, (2018), Nature Medicine, 24, 1507 - 1512
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Journal article
Edwards TL. et al, (2018), Nature Biomedical Engineering, 2, 649 - 656
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Journal article
Edwards TL. et al, (2018), Ophthalmology, 125, 432 - 443
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Journal article
Edwards TL. et al, (2016), New England Journal of Medicine, 374, 1996 - 1998
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Journal article
Xue K. et al, (2006), Journal of Experimental Medicine, 203, 2085 - 2094
Recent publications
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Journal article
Chandler LC. et al, (2023), Mol Ther Methods Clin Dev, 28
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Journal article
von Krusenstiern L. et al, (2023), JAMA Ophthalmology, 141, 275 - 275
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Journal article
John MC. et al, (2023), Frontiers in Molecular Neuroscience, 15
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Journal article
Chang ET. et al, (2022), Ophthalmology
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Journal article
Li F. et al, (2022), J Clin Invest, 132
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Journal article
Zhu J. et al, (2022), MedComm – Future Medicine, 1
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Chapter
Song WK. et al, (2022), Albert and Jakobiec's Principles and Practice of Ophthalmology: Fourth Edition, 3997 - 4012
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Journal article
Cehajic-Kapetanovic J. et al, (2021), Am J Ophthalmol
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Journal article
Chandler LC. et al, (2021), Molecular Therapy - Methods & Clinical Development, 22, 52 - 65
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Journal article
de Pennington N. et al, (2021), JMIR Res Protoc, 10