Dr Alastair Webb joined the Centre for Prevention of Stroke and Dementia in 2010 on an MRC Clinical Research Fellowship, completing an MSc and a DPhil. He has continued to work as an Associate Clinical Fellow with the CPSD whilst completing his clinical training as a neurology registrar in Oxford. He has recently been awarded a Wellcome Trust Clinical Research Development Fellowship for further research within the CPSD, to coincide with becoming a Neurology Consultant in August 2017.
Dr Webb's research is focussed on the physiological relationship between blood pressure and stroke risk, beyond the effects of mean blood pressure. His early work used meta-analyses of published results of randomised controlled clinical trials to demonstrate that different antihypertensive medications have parallel effects on blood pressure variability and stroke risk. He subsequently established a physiological cohort study, nested within the CPSD flagship cohort (OXVASC), to identify novel physiological indices that predict the future risk of stroke, chronic cerebrovascular injury and cognitive impairment. This ongoing study has identified indices such as arterial stiffness, blood pressure variability and cerebral arterial pulsatility as potential treatment targets. Future work will aim to develop a program of clinical trials to modify these adverse physiological indices to hopefully reduce the risk of stroke and cognitive decline.
MA BMBCh MSc MRCP(Neurol) DPhil
Modifying the relationship between cardiovascular physiology and the risk of stroke
Associate Clinical Fellow / Neurology Registrar
Prognostic Significance of Blood Pressure Variability on Beat-to-Beat Monitoring After Transient Ischemic Attack and Stroke.
Webb AJS. et al, (2018), Stroke, 49, 62 - 67
Acute variegate porphyria presenting with reversible cerebral vasoconstriction.
Webb AJS. et al, (2016), Clin Neurol Neurosurg, 146, 102 - 104
Magnetic Resonance Imaging Measurement of Transmission of Arterial Pulsation to the Brain on Propranolol Versus Amlodipine.
Webb AJS. and Rothwell PM., (2016), Stroke, 47, 1669 - 1672
Seasonal variation in Guillain-Barré syndrome: a systematic review, meta-analysis and Oxfordshire cohort study.
Webb AJS. et al, (2015), J Neurol Neurosurg Psychiatry, 86, 1196 - 1201
Superficial siderosis following spontaneous intracranial hypotension.
Webb AJS. et al, (2015), Pract Neurol, 15, 382 - 384