Contact information
Collaborators
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Karla Miller
Professor of Biomedical Engineering
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Saad Jbabdi
Professor of Biomedical Engineering
Amy Howard
Post-Doctoral Researcher in Diffusion MRI
Combining diffusion MRI and microscopy to probe tissue microstructure
What can we learn from highly detailed microscopy images that can help us infer brain connectivity in vivo? My research considers different ways in which we can combine complementary data from both microscopy and diffusion MRI, to both validate and drive biophysical modelling of the brain tissue microstructure.
Recently, our focus has been on collecting an extensive dataset, the BigMac dataset, which combines ultra-HARDI and microscopy (polarised light imaging and histology) data from the same, single brain. This dataset will provide an open access platform to interconnect microstructural features with MR signals throughout the brain.
At FMRIB, my research spans both the physics and analysis groups and is co-supervised by Profs Karla Miller & Saad Jbabdi.
Interests include:
- In vivo & postmortem MRI
- Diffusion MRI connectivity & microstructure imaging
- Biophysical modelling & model validation
- Light microscopy: polarised light imaging & histological staining
- Quantitative analysis of histology (structure tensor analysis & cell segmentation)
- MRI-microscopy co-registration
- Data fusion / joint analysis of MRI and microscopy (e.g. hybrid tractography)
Recent publications
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Estimating axial diffusivity in the NODDI model
Journal article
Howard AFD. et al, (2022), NeuroImage, 262, 119535 - 119535
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Post mortem mapping of connectional anatomy for the validation of diffusion MRI.
Journal article
Yendiki A. et al, (2022), Neuroimage, 256
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The Digital Brain Bank, an open access platform for post-mortem imaging datasets.
Journal article
Tendler BC. et al, (2022), Elife, 11
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Toward next-generation primate neuroscience: A collaboration-based strategic plan for integrative neuroimaging
Journal article
Milham M. et al, (2021), Neuron
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Joint modelling of diffusion MRI and microscopy
Journal article
Howard A. et al, (2019), NeuroImage
Websites
- FMRIB Physics Research
- FMRIB Analysis Research
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Oxford-Nottingham Biomedical Imaging (ONBI)
Centre for Doctoral Training