Research groups
Colleges
Websites
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Kavli Institute for Nanoscience Discovery
Member
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Interdisciplinary Life and Environmental Science Landscape Award - Doctoral Training Programme
Co-Director
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Oxford Interdisciplinary Bioscience DTP
Co-Director
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Society for Research on the Cerebellum and Ataxias
President
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AcademiaNet - Expert Database for Outstanding Female Academics
Member
Esther Becker
PhD MSc
Professor of Translational Neuroscience
Esther graduated from the University of Amsterdam cum laude with a MSc degree in Medical Biology in 2000. She then joined the Biomedical and Biological Sciences program at Harvard University, where she performed her PhD training with Azad Bonni. Her work as a graduate student has made significant contributions to our understanding of the specific signaling mechanisms that regulate cell death in the nervous system, particularly in the developing cerebellum. For her graduate studies, Esther was awarded a PhD Fellowship from the Boehringer Ingelheim Fonds and an Albert J. Ryan Foundation Fellowship.
After completing her PhD in 2006, Esther joined Kay Davies’ group in the Department of Physiology, Anatomy and Genetics, having been awarded a Human Frontier Science Program Fellowship and later an OXION Training Fellowship. In 2010, Esther was awarded a prestigious Dorothy Hodgkin Research Fellowship from the Royal Society to establish her own research programme, focussing on the genetic and molecular underpinnings of cerebellar ataxia in mice and humans. Esther joined the Nuffield Department of Clinical Neurosciences in 2020. She is also Co-Director of the Oxford Interdisciplinary Bioscience Doctoral Training Partnership and the newly awarded Interdisciplinary Life and Environmental Science Landscape Award (ILESLA). Esther is Official Fellow (Cellular Life) at Reuben College.
The Becker group aims to understand the genetic, molecular and cellular mechanisms that underlie neurodevelopmental and neurodegenerative diseases of the cerebellum with the ultimate aim of developing better treatments for these disorders.
Key publications
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Dominant Mutations in GRM1 Cause Spinocerebellar Ataxia Type 44
Journal article
Watson LM. et al, (2017), The American Journal of Human Genetics, 101, 451 - 458
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A Simplified Method for Generating Purkinje Cells from Human-Induced Pluripotent Stem Cells
Journal article
Watson LM. et al, (2018), The Cerebellum, 17, 419 - 427
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The mutant Moonwalker TRPC3 channel links calcium signaling to lipid metabolism in the developing cerebellum
Journal article
Dulneva A. et al, (2015), Human Molecular Genetics, 24, 4114 - 4125
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Do mutations in the murine ataxia geneTRPC3cause cerebellar ataxia in humans?
Journal article
Fogel BL. et al, (2015), Movement Disorders, 30, 284 - 286
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A point mutation in TRPC3 causes abnormal Purkinje cell development and cerebellar ataxia in moonwalker mice
Journal article
Becker EBE. et al, (2009), Proceedings of the National Academy of Sciences, 106, 6706 - 6711
Recent publications
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Conference Report: Cerebellar Development and Disease at Single-Cell Resolution.
Journal article
Kutscher LM. et al, (2025), Cerebellum, 24
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Enhanced mGluR1 function causes motor deficits and region-specific Purkinje cell dysfunction
Preprint
Ibrahim MF. et al, (2025)
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Sonic hedgehog medulloblastoma cells in co-culture with cerebellar organoids converge towards in vivo malignant cell states
Journal article
JACOB J., (2025), Neuro-Oncology Advances
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ARSACS: Clinical Features, Pathophysiology and iPS-Derived Models.
Journal article
Salem IH. et al, (2025), Cerebellum, 24
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Cerebellar organoids model cell type-specificFOXP2expression during human cerebellar development
Preprint
Apsley EJ. et al, (2024)