Jason Lerch
Professor of Neuroscience
Jason Lerch is the director of Preclinical Imaging at the Wellcome Centre for Integrative Neuroimaging (WIN) at the University of Oxford, an adjunct scientist at the Mouse Imaging Centre (MICe) of the Hospital for Sick Children and an associate professor in medical biophysics at the University of Toronto.
Lerch joined WIN in March of 2019; prior to that, he completed his PhD in 2005 in the Department of Neurology and Neurosurgery at McGill University and a postdoctoral fellowship at MICe from 2005 to 2008 with Mark Henkelman and John Sled. He received his BA in 1999 in anthropology and social studies of medicine from McGill University. His PhD research, under the supervision of Alan Evans, was on in vivo measurements of cortical thickness from magnetic resonance imaging scans.
Key publications
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Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity.
Journal article
Ellegood J. et al, (2015), Mol Psychiatry, 20, 118 - 125
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Mouse MRI shows brain areas relatively larger in males emerge before those larger in females.
Journal article
Qiu LR. et al, (2018), Nat Commun, 9
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Studying neuroanatomy using MRI
Other
Lerch JP. et al, (2017), Nature Neuroscience, 20, 314 - 326
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Structural covariance of brain region volumes is associated with both structural connectivity and transcriptomic similarity.
Journal article
Yee Y. et al, (2018), Neuroimage, 179, 357 - 372
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Maze training in mice induces MRI-detectable brain shape changes specific to the type of learning.
Journal article
Lerch JP. et al, (2011), Neuroimage, 54, 2086 - 2095
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Examining overlap and homogeneity in ASD, ADHD, and OCD: a data-driven, diagnosis-agnostic approach.
Journal article
Kushki A. et al, (2019), Transl Psychiatry, 9
Recent publications
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Cortico-amygdalar connectivity and externalizing/internalizing behavior in children with neurodevelopmental disorders.
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Nakua H. et al, (2022), Brain Struct Funct
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Genetic mouse models of autism spectrum disorder present subtle heterogenous cardiac abnormalities.
Journal article
Assimopoulos S. et al, (2022), Autism Res
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Mouse models of immune dysfunction: their neuroanatomical differences reflect their anxiety-behavioural phenotype.
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Fernandes DJ. et al, (2022), Mol Psychiatry
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Differential effects of early or late exposure to prenatal maternal immune activation on mouse embryonic neurodevelopment.
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Guma E. et al, (2022), Proc Natl Acad Sci U S A, 119
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Shared and Distinct Patterns of Functional Connectivity to Emotional Faces in Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder Children
Journal article
Safar K. et al, (2022), Frontiers in Psychology, 13
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