Funding
Co-Investigator MRC Research Grant (2015-2019)
MRC New Investigator Research Grant Holder (present)
Research groups
Colleges
Collaborators
-
David Bennett
Professor of Neurology and Neurobiology
-
Sarosh Irani
Collaborator, Oxford Autoimmune Neurology Group
John Dawes
Associate Professor
- MRC New Investigator
- Retained Lecturer in Neurophysiology, Wadham College
Research Summary
It is now well established that the immune system contributes to pathological pain sates and one relatively under studied aspect of this is through the action of autoantibodies. Neuropathic pain is common in patients with autoantibodies directed against components of the voltage gated potassium channel complex such as CASPR2 and LGI1. By using patient samples in combination with basic pain research my aim is to better understand the mechanisms of autoantibody mediated pain and by doing so uncover novel molecular pathways regulating pain sensitivity as well as revealing clinically relevant targets for the development of future therapies.
Key publications
-
Journal article
Dawes JM. et al, (2018), Neuron, 97, 806 - 822.e10
-
Journal article
Dawes JM. and Vincent A., (2016), Current Opinion in Supportive & Palliative Care, 10, 137 - 142
-
Journal article
Dawes JM. et al, (2011), Science Translational Medicine, 3, 90ra60 - 90ra60
-
Journal article
Calvo M. et al, (2012), The Lancet Neurology, 11, 629 - 642
-
Autoantibodies and neuropathic pain
Chapter
Dawes JM. and Bennett DL., (2018), The Oxford Handbook of the Neurobiology of Pain, 833 - 850
Recent publications
-
Journal article
Ramanathan S. et al, (2021), Annals of Neurology, 90, 683 - 690
-
Journal article
Middleton SJ. et al, (2021), Journal of Anatomy
-
Journal article
Dawes JM. and Bennett DL., (2021), Neuron, 109, 2641 - 2642
-
Autism Spectrum Disorders: Multiple Routes to, and Multiple Consequences of, Abnormal Synaptic Function and Connectivity
Journal article
Carroll L. et al, (2020), The Neuroscientist: reviews at the interface of basic and clinical neurosciences
-
Journal article
Baskozos G. et al, (2019), Pain, 160, 463 - 485