Dr Lucy Farrimond
Clinical Research Fellow
I am a Neurology Registrar and Wellcome Trust Clinical Research Fellow at the Oxford Motor Neuron Disease Centre with an interest in mechanisms of motor neuron degeneration in motor neuron disease, also known as amyotrophic lateral sclerosis (ALS).
After qualifying in medicine (BM BCh) with distinction from the University of Oxford in 2012, I was awarded an NIHR Academic Foundation post in Oxford where I first joined Professor Kevin Talbot’s research group studying mouse models of ALS. I subsequently gained an NIHR Academic Clinical Fellowship in Neurology where I continued this work alongside clinical training in acute medicine and neurology. In 2018 I was awarded a Wellcome Trust Clinical Research Fellowship to study cellular models of ALS.
At present, I am working towards a DPhil under the supervision of Kevin Talbot, Colin Akerman and Ruxandra Dafinca. In my current work, I am applying optogenetic technology to neurons derived from induced pluripotent stem cells to understand the relationship between activity and neurodegeneration in ALS.
Advantages of routine next generation sequencing over standard genetic testing in the ALS clinic.
Scaber J. et al, (2023), Eur J Neurol
Human iPSC co-culture model to investigate the interaction between microglia and motor neurons
Vahsen BF. et al, (2022), Scientific Reports, 12
A case of SOD1 deficiency: implications for clinical trials.
Farrimond L. and Talbot K., (2022), Brain
Multicentre appraisal of amyotrophic lateral sclerosis biofluid biomarkers shows primacy of blood neurofilament light chain
Thompson AG. et al, (2022), Brain Communications, 4
Impairment of mitochondrial calcium buffering links mutations in C9orf72 and TARDBP in iPS-derived motor neurons from patients with ALS/FTD
DAFINCA R. et al, (2020), Stem Cell Reports