Senior Post-doctoral Research Scientist
I joined the research group of Prof Beeson in 2000 after the completion of my PhD from the University of London. I’m interested in the functional analysis of neuromuscular transmission from the whole animal to the single channel. I am a senior electrophysiologist with expertise in many aspects of measuring neurotransmission. Our goal is to understand the molecular mechanisms that enable neuromuscular transmission and to determine what underlies the pathophysiology seen in patients with Congenital Myasthenic Syndromes.
IgG1-3 MuSK Antibodies Inhibit AChR Cluster Formation, Restored by SHP2 Inhibitor, Despite Normal MuSK, DOK7, or AChR Subunit Phosphorylation.
Cao M. et al, (2023), Neurol Neuroimmunol Neuroinflamm, 10
NSC-87877, INHIBITOR OF SRC HOMOLOGY 2 DOMAIN-CONTAINING PHOSPHOTYROSINE PHOSPHATASE 2, AMELIORATES EXPERIMENTAL AUTOIMMUNE MYASTHENIA GRAVIS INDUCED BY MUSK IMMUNIZATION
Yilmaz V. et al, (2022), MUSCLE & NERVE, 65, S45 - S45
The Structure, Function, and Physiology of the Fetal and Adult Acetylcholine Receptor in Muscle.
Cetin H. et al, (2020), Front Mol Neurosci, 13
Interaction of Axonal Chondrolectin with Collagen XIXa1 Is Necessary for Precise Neuromuscular Junction Formation.
Oprişoreanu A-M. et al, (2019), Cell Rep, 29, 1082 - 1098.e10
Animal Models of the Neuromuscular Junction, Vitally Informative for Understanding Function and the Molecular Mechanisms of Congenital Myasthenic Syndromes
Webster R., (2018), International Journal of Molecular Sciences, 19, 1326 - 1326