Contact information
Colleges
BIOGRAPHY
Kanmin Xue is a Wellcome Trust clinician scientist fellow at the University of Oxford and Honorary Consultant Vitreoretinal Surgeon at the Oxford Eye Hospital. He previously held the role of National Institute for Health and Care Research (NIHR) Academic Clinical Lecturer in Oxford between 2014 and 2018, conducting laboratory and clinical research into gene therapy for inherited retinal diseases, robotic eye surgery and artificial retinal implant with Professor Robert MacLaren. He has completed the UK specialist training in ophthalmology and a vitreoretinal fellowship at the Royal Victorian Eye and Ear Hospital in Melbourne, Australia. He previously conducted PhD research at the MRC Laboratory of Molecular Biology in Cambridge into how DNA editing brings about antibody class switching, underwent clinical training at Trinity College Cambridge, and pre-clinical training at Brasenose College Oxford, where he was awarded Martin Wronker Prize for the top First Class in Medicine.
AWARDS
EURETINA Retinal Medicine Clinical Research Award 2025
Ruskell Medal 2019
Ian Fraser Cup 2017
Luigi Barca Award 2017
Martin Wronker Prize in Medicine 2003
Websites
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Modern Retina
Shedding light on retinal inflammation after gene therapy
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Fight for Sight
How gene therapy can be applied to a multitude of sight loss conditions
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Retina UK Conference Talk
Practical example of gene therapy
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Retina UK Podcast
Cataract surgery for patients with inherited retinal degenerations
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Oxford Medicine Magazine
Summer 2024 - Gene Therapy for Retinal Disease
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BBC News
AI assistant, Dora, eases NHS pressure in cataract care
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Eyetube
Clinical challenges of AAV vectors
Kanmin Xue
MA MBBChir PhD FRCOphth
Associate Professor
- Honorary Consultant Vitreoretinal Surgeon, Oxford University Hospitals & Great Ormond Street Hospital for Children, London
- Member of Senior Common Room (former Medical Research Fellow), Corpus Christi College, Oxford
Research
The retina is an accessible part of the central nervous system and an ideal organ for studying neurodegeneration and assessing novel gene therapies. Kanmin leads the Retinal Disease and Repair Group, which is currently focused on investigating the mechanisms of retinal degeneration and inflammation in the context of age-related macular degeneration (AMD) and uveitis. Improved understanding of these diseases supports the development of novel therapeutic approaches, including viral and non-viral vector-mediated gene delivery, gene editing, and antisense oligonucleotide therapies. Clinical translation is aided by a multi-disciplinary approach, involving patient cohort studies, interventional clinical trials, and application of artificial intelligence (AI).
Team members
Molly John, DPhil candidate (Exeter College)
Monica Hu, DPhil candidate & Clarendon Scholar (Merton College)
Lakshanie Wickramasinghe, collaborating Post-doctoral Research Scientist & Knoop Junior Research Fellow in Ophthalmology (St Cross College)
Joel Jong, Academic Foundation Doctor
Past Group Members
Celia Sourd, Post-doctoral Research Scientist
Joel Quinn, DPhil & MRC Scholar (Merton College)
Emer Chang, Academic Foundation Doctor (St Hugh's College)
- Early Career Researcher Award, Oxford Ophthalmological Congress 2024
Laurel Chandler, DPhil (Merton College)
- Thomas Willis Poster Prize 2019
- Oxford-Bristol-Cardiff-Southampton Alliance in Vision Research Best Poster Prize 2017
Ayesha Musa, FHS student 2020 (Jesus College)
James Aylward, BM-BCh (St Hilda's College)
Dun Jack Fu, BM-BCh PhD (St Hugh's College)
Olivia Parham, FHS student 2016 (New College)
Howell Fu, FHS student 2015 (Exeter College)
Research groups
Collaborators
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Robert MacLaren
Professor of Ophthalmology
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Jasmina Cehajic-Kapetanovic
MRC Clinician Scientist and Consultant Vitreo-Retinal Surgeon
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Samantha de Silva
Consultant Ophthalmologist
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Dominik Fischer
Professor of Ophthalmology
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Michelle McClements
Senior Postdoctoral Research Scientist
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Amandeep Josan
Specialist Optometrist
Key publications
Single-cell transcriptomic analysis of retinal immune regulation and blood-retinal barrier function during experimental autoimmune uveitis
Journal article
Quinn J. et al, (2024), Scientific Reports, 14
Accuracy and safety of an autonomous artificial intelligence clinical assistant conducting telemedicine follow-up assessment for cataract surgery
Journal article
Meinert E. et al, (2024), eClinicalMedicine, 73, 102692 - 102692
A Network Meta-Analysis of Retreatment Rates following Bevacizumab, Ranibizumab, Aflibercept, and Laser for Retinopathy of Prematurity
Journal article
Chang E. et al, (2022), Ophthalmology, 129, 1389 - 1401
Characterizing the cellular immune response to subretinal AAV gene therapy in the murine retina
Journal article
Chandler LC. et al, (2021), Molecular Therapy - Methods & Clinical Development, 22, 52 - 65
Genome-Editing Strategies for Treating Human Retinal Degenerations
Journal article
Quinn J. et al, (2021), Human Gene Therapy, 32, 247 - 259
Initial results from a first-in-human gene therapy trial on X-linked retinitis pigmentosa caused by mutations in RPGR
Journal article
Cehajic-Kapetanovic J. et al, (2020), Nature Medicine, 26, 354 - 359
Enhancement of Adeno-Associated Virus-Mediated Gene Therapy Using Hydroxychloroquine in Murine and Human Tissues
Journal article
Chandler LC. et al, (2019), Molecular Therapy - Methods & Clinical Development, 14, 77 - 89
Beneficial effects on vision in patients undergoing retinal gene therapy for choroideremia
Journal article
Xue K. et al, (2018), Nature Medicine, 24, 1507 - 1512
First-in-human study of the safety and viability of intraocular robotic surgery
Journal article
Edwards TL. et al, (2018), Nature Biomedical Engineering, 2, 649 - 656
Assessment of the Electronic Retinal Implant Alpha AMS in Restoring Vision to Blind Patients with End-Stage Retinitis Pigmentosa
Journal article
Edwards TL. et al, (2018), Ophthalmology, 125, 432 - 443
Recent publications
Geographic atrophy in age-related macular degeneration: phenotypic characterisation for clinical trial consideration.
Journal article
Borchert GA. et al, (2026), Graefes Arch Clin Exp Ophthalmol
Multimodal imaging and electrophysiological features in bradyopsia associated with homozygous variants (c.895T>C) in Regulator of G-protein Signaling 9 (RGS9).
Journal article
Borchert GA. et al, (2026), Ophthalmic Genet, 47, 14 - 21
Methotrexate‐Loaded Liposomal Formulation Enables 6‐Week Sustained Intraocular Therapeutic Drug Release in a Porcine Model
Journal article
Hammer M. et al, (2026), Advanced Healthcare Materials, 15
Case series: Transient neonatal macular retinoschisis - a developmental phenomenon in term infants.
Journal article
Purohit R. et al, (2025), Eye (Lond), 39, 3359 - 3364
Physiological responses to retinopathy of prematurity screening: indirect ophthalmoscopy versus ultra-widefield retinal imaging.
Journal article
Purohit R. et al, (2025), Pediatr Res, 98, 1801 - 1808
Risk factors of late intraocular Lens displacement: A multi-national study.
Journal article
Chipeta C. et al, (2025), Eur J Ophthalmol, 35, 2001 - 2009
Reply to Comment on “Retinal vascularization rate predicts retinopathy of prematurity and remains unaffected by low-dose bevacizumab treatment”
Journal article
Chang E. et al, (2025), American Journal of Ophthalmology, 277, 582 - 583
Single-cell and spatial transcriptomic analyses of gene therapy-associated retinal inflammation in non-human primates
Preprint
Sourd C. et al, (2025)
Single-cell and spatial transcriptomic analyses of gene therapy-associated retinal inflammation in non-human primates
Journal article
XUE K. et al, (2025), BioRxiv
Retinal Vascularization Rate Predicts Retinopathy of Prematurity and Remains Unaffected by Low-Dose Bevacizumab Treatment
Journal article
Chang E. et al, (2025), American Journal of Ophthalmology, 275, 74 - 87