Contact information
BIOGRAPHY
Dr Kapetanovic is an MRC Clinician Scientist and a vitreo-retinal surgeon, working with the Clinical Ophthalmology Research Group of Professor MacLaren. She received her undergraduate (MA in Physiological Sciences, Balliol College) and medical degrees at the University of Oxford. She was awarded the UK's first NIHR integrated clinical academic fellowship programme in ophthalmology and has since awarded Masters in Investigative Ophthalmology and Visual Science (First Class) and a PhD in Medicine (gene therapy and optogenetics) via the MRC Clinical Research Training Fellowship at the University of Manchester, UK. Her PhD in optogenetic vision restoration was awarded the prestigious Russell Medal for the best UK paper in vision research and several outstanding awards including the MRC Centenary Award and Retinitis Pigmentosa Fighting Blindness Award. As a Keeler scholar at the University of California, Berkeley, she conducted a post-doctoral research into adeno-associated vector biology for ocular applications, under the mentorship of Professor Flannery. She completed the specialist training and was admitted as a fellow (FRCOphth) into the UK Royal College of Ophthalmologists and has won over 30 awards during her early career as an academic ophthalmologist. She is a consultant ophthalmic surgeon specialised in cataract and vitreoretinal surgery, and as an MRC Clinician Scientist she is currently working on developing innovative surgical techniques including robot-assisted retinal surgery for future applications in genetic therapies.
TEAM MEMBERS
Hoda Shamsnajafabadi - Post Doctoral Research Assistant
Grace Borchert - DPhil Student
Jędrzej Golebka - Medical Student
Previous Students:
Federica Staurenghi, MSc (Research) Cinical Neurosciences, Oxford University
Mana Rahimzadeh, Academic Medical Student, New College, Oxford University
James Aylward BMBCh, St Hilda's College, Oxford University
Abigail Pienaar, MA in Neurosciences, University of Manchester, 2014-2015 (Distinction)
Abigail Blackwell, MA in Neurosciences, University of Manchester, 2013-2014 (Distinction)
Websites
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Nature Biomedical Engineering
Sight Restoring approaches
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Ocular Surgery News
Enormous’ potential of robotics opens door to next revolution in eye surgery
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BBC News
Gene Therapy to halt rare form of sight loss
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NIHR Oxford BRC
Early career profile: Dr Jasmina Cehajic Kapetanovic
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CLINICAL TRIALS
Co-Principal Investigator
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BBC News
First in-human gene therapy for AMD
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Be part of the next breakthrough
CHOROIDEREMIA RESEARCH
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FIGHT FOR SIGHT
Dr Kapetanovic's FIGHT FOR SIGHT
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Optometry Today
Bayer announces recipients of this year’s Global Ophthalmology Awards Programme
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KCW Today
AI and robotics in healthcare
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Foundation Fighting Blindness
Robot Assisted Retinal Surgery
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The Worshipful Company of Spectacle Makers
The Ruskell Medal Winner
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Blind Mice Treatment May Help Humans
The Times
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Gene therapy cures blindness by replacing vision cells in eyes
New Scientist
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Science2Go
MRC Clinical Training Research Fellowship
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Optogenetics: From Neuronal Function to Mapping and Disease Biology
Cambridge University Press
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Cure for Blindness
Mirror
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Sight Restoring Treatment Hits a Nerve
Optometry Today
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Moving Closer to Curing Common Cause of Blindness
Neuroscience News
Dr Jasmina Cehajic Kapetanovic
M.A. Phy. Sci., B.M. B.Ch. Oxon., M.Sc. I.O.V.S., Ph.D., F.R.C.Ophth.
MRC Clinician Scientist and Consultant Vitreo-Retinal Surgeon
- Honorary Clinician Scientist, Moorfields Eye Hospital, London, UK
- Honorary Clinician Scientist, Manchester Royal Eye Hospital and University of Manchester, Manchester, UK
Restoring Vision with Gene Therapy and Optogenetics and Developing Robot-Assisted Retinal Surgery
RESEARCH
Dr Kapetanovic's research focuses on vision restoration and development of therapies for inherited retinal degenerations, the leading cause of blindness in the working population, as well as therapies for a more common form of blindness, the dry age related macular degeneration (AMD). Together with Professor MacLaren, she is currently leading gene therapy trials for choroideremia, RPGR X-linked retinitis pigmentosa and dry AMD at clinical centres at Oxford, Manchester and the Moorfields Eye Hospital in London. She is also involved in the Retinal Implant programme and developing surgical techniques for retinal gene therapy including the innovative robot-assisted vector delivery. Her laboratory based research focuses on developing novel optogenetic strategies and improving the efficacy of gene delivery to the retina. She was recently awarded an MRC Clinician Scientist Fellowship Award to continue working at this cutting edge research.
AWARDS
The 2020 Ruskell Medal Runner Up, The Worshipful Company of Spectacle Makers Research Awards, UK
American Society of Gene and Cell Therapy Excellence in Research Award, 2020
American Society of Gene and Cell Therapy Meritorious Abstract Travel Award, 2020
Global Ophthalmology Awards Programme Fellowship, Bayer, 2018/2019
International Congress of Ophthalmological Societies Research Award, 2017
The Academy of Medical Sciences Research Prize, London, 2017
The 2016 Ruskell Medal, The Worshipful Company of Spectacle Makers Research Awards, London, 2016
Post-Doctoral Clinical Research Fellowship, Helen Wills Neuroscience Institute, University of California, Berkeley, 2015
Retinitis Pigmentosa Fighting Blindness Post Doctoral Research Award, 2015
The MRC Centenary Award, 2014
The Keeler Scholarship Award, 2014
The Confidence in Concept Award, Medical Research Council, UK, 2014
The David McLeod Research Cup, University of Manchester, 2014
The John Lee Prize, Royal College of Ophthalmologists, London, 2013
The Dickinson Trust Award, Manchester, 2013
The Research and Innovation Award, Manchester Biomedical Research Centre, Manchester, 2012
The North of England Ophthalmological Society Award, 2011
The Academy of Medical Sciences Research Prize, London, 2011
The National Institute for Health and Research, Biomedical Research Centre Award, 2011
The MRC Clinical Research Training Fellowship, 2010
The Daniel Turnberg Cup Runner Up, University of Manchester 2010
The Annual Alcon Achievement Research Award, Manchester 2009 and 2008
The Andrew Tullo Research Cup, Manchester, 2008 and 2007
Integrated Academic Training Award, North Western Deanery and University of Manchester, 2007
NIHR Academic Clinical Fellowship, 2006
John Potter Prize in Neurology and Neurosurgery, University of Oxford, 2002
Oxford University Psychiatry Prize, University of Oxford, 2001
Distinction in Experimental Dissertation in Neuropharmacology, University of Oxford, 1999
Research groups
Collaborators
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Robert MacLaren
Professor of Ophthalmology
Key publications
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Journal article
Cehajic-Kapetanovic J. et al, (2020), Nature Medicine, 26, 354 - 359
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Journal article
Cehajic-Kapetanovic J. et al, (2015), Current Biology, 25, 2111 - 2122
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Journal article
Cehajic-Kapetanovic J. et al, (2022), Proceedings of the National Academy of Sciences, 119
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Journal article
McClements ME. et al, (2020), Frontiers in Neuroscience, 14
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Journal article
Cehajic-Kapetanovic J. et al, (2022), Nat Biomed Eng
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Journal article
Cehajic-Kapetanovic J. et al, (2021), Am J Ophthalmol
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Journal article
Quinn J. et al, (2021), Human Gene Therapy, 32, 247 - 259
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Journal article
Cehajic-Kapetanovic J. et al, (2019), JAMA Netw Open, 2
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Journal article
Cehajic Kapetanovic J. et al, (2019), Genes (Basel), 10
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Journal article
Cehajic Kapetanovic J. et al, (2020), Acta Ophthalmologica, 98, 736 - 740
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Journal article
Cehajic-Kapetanovic J. et al, (2018), Molecular Therapy - Methods & Clinical Development, 9, 192 - 202
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Journal article
Milosavljevic N. et al, (2016), Current Biology, 26, 2358 - 2363
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Journal article
Murenu E. et al, (2021), Molecular Therapy - Methods & Clinical Development
Recent publications
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Journal article
von Krusenstiern L. et al, (2023), JAMA Ophthalmology, 141, 275 - 275
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Journal article
John MC. et al, (2023), Frontiers in Molecular Neuroscience, 15
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Journal article
Han RC. et al, (2023), Ophthalmic Genetics, 1 - 8
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Journal article
Cehajic-Kapetanovic J. et al, (2022), Proceedings of the National Academy of Sciences, 119
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Journal article
Buckley TMW. et al, (2022), American Journal of Ophthalmology Case Reports, 28
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Journal article
Martinez-Fernandez de la Camara C. et al, (2022), Expert Opin Emerg Drugs, 27, 449 - 450
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Journal article
Elsayed MEAA. et al, (2022), Genes (Basel), 13
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Journal article
Martinez-Fernandez de la Camara C. et al, (2022), Expert Opinion on Emerging Drugs, 27, 431 - 443
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Impaired glutamylation of ORF15 presents a unique phenotype in RPGRrelated retinal dystrophy
Conference paper
Kapetanovic JC. et al, (2022), INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 63
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RPGR(ORF15) glutamylation impaired by mutations in its C-terminal basic domain
Conference paper
dela Camara CM-F. et al, (2022), INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 63
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Journal article
Buckley TMW. et al, (2022), Transl Vis Sci Technol, 11
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Journal article
Cehajic-Kapetanovic J. et al, (2022), Nat Biomed Eng
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Correlation between fundus autofluorescence pattern and retinal sensitivity measured by microperimetry in patients with choroideremia
Conference paper
Poli FE. et al, (2022), INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 63
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Chapter
MacLaren RE. and Cehajic-Kapetanovic J., (2022), Clinical Ophthalmic Genetics and Genomics, 63 - 66
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Journal article
Buckley TMW. et al, (2021), Acta Ophthalmologica, 99, 819 - 825
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Journal article
Cehajic-Kapetanovic J. et al, (2021), Am J Ophthalmol
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Journal article
Josan AS. et al, (2021), Translational Vision Science & Technology, 10, 12 - 12
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Journal article
Cehajic‐Kapetanovic J. et al, (2021), Acta Ophthalmologica, 99, 441 - 447
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Journal article
Quinn J. et al, (2021), Human Gene Therapy, 32, 247 - 259
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Journal article
McClements ME. et al, (2021), BioMed Research International, 2021, 1 - 8
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Journal article
Murenu E. et al, (2021), Molecular Therapy - Methods & Clinical Development
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Chapter
Kantor A. et al, (2021), Progress in Molecular Biology and Translational Science
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Journal article
Menghini M. et al, (2021), Ophthalmologica, 244, 281 - 290
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Journal article
McClements ME. et al, (2020), Frontiers in Neuroscience, 14
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Journal article
Cehajic Kapetanovic J. et al, (2020), Acta Ophthalmologica, 98, 736 - 740
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Journal article
Cehajic-Kapetanovic J. et al, (2020), JAMA Ophthalmology
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Journal article
Wood LJ. et al, (2020), Clinical and Experimental Optometry
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Journal article
Cehajic-Kapetanovic J. et al, (2020), Ophthalmic Genetics, 41, 288 - 292
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Journal article
Stevanovic M. et al, (2020), Acta Ophthalmologica, 98
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Journal article
Cehajic-Kapetanovic J. et al, (2020), Nature Medicine, 26, 354 - 359
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Journal article
MacDonald IM. et al, (2020), Translational Vision Science & Technology, 9, 17 - 17
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Journal article
Martinez-Fernandez De La Camara C. et al, (2020), Expert Opinion on Biological Therapy, 20, 63 - 71
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Journal article
Menghini M. et al, (2020), Expert Opin Orphan Drugs, 8, 67 - 78
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Journal article
Menghini M. et al, (2019), Ophthalmic Genetics, 40, 545 - 548
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Journal article
Cehajic Kapetanovic J. et al, (2019), Expert Review of Ophthalmology, 14, 277 - 285
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Journal article
Cehajic Kapetanovic J. et al, (2019), Genes (Basel), 10
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Journal article
Cehajic Kapetanovic J. et al, (2019), Genes (Basel), 10
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Correlation of distinct fundus autofluorescence features with disruption of the overlying ellipsoid zone in choroideremia
Conference paper
Stevanovic M. et al, (2019), INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 60
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Journal article
Cehajic-Kapetanovic J. et al, (2019), JAMA Netw Open, 2
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Journal article
Cehajic-Kapetanovic J. et al, (2019), Ophthalmic Genetics, 40, 29 - 33
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Journal article
Cehajic-Kapetanovic J. et al, (2018), Molecular Therapy - Methods & Clinical Development, 9, 192 - 202
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Journal article
Cehajic Kapetanovic J. et al, (2018), BMJ Case Reports
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Journal article
Kapetanovic JC. et al, (2017), The Lancet, 389, S30 - S30
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Meclofenamic acid improves the signal to noise ratio for visual responses produced by ectopic expression of human rod opsin.
Journal article
Eleftheriou CG. et al, (2017), Mol Vis, 23, 334 - 345
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Journal article
Milosavljevic N. et al, (2016), Investigative Opthalmology & Visual Science, 57, 6305 - 6305
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Journal article
Milosavljevic N. et al, (2016), Current Biology, 26, 2358 - 2363
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Journal article
Cehajic-Kapetanovic J. et al, (2015), Current Biology, 25, 2111 - 2122
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Journal article
Cehajic-Kapetanovic J. et al, (2014), The Lancet, 383, S33 - S33
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Journal article
Cehajic-Kapetanovic J. et al, (2013), The Lancet, 381, S29 - S29
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Journal article
Talic A. et al, (2012), Materia Socio Medica, 24, 16 - 16