Wolfson Centre for Prevention of Stroke and Dementia
We increase understanding of the causes of cerebrovascular disease and improve the prevention of stroke and vascular dementia in routine clinical practice.
For Clinicians
Contact
t: 01865 231601
The Wolfson Centre for the Prevention of Stroke and Dementia (CPSD) is the UK’s first purpose-built research centre focussed specifically on prevention of cerebrovascular disease. The CPSD builds on the Stroke Prevention Research Unit (SPRU), which was founded by Professor Rothwell in 2000 and was awarded a Queen’s Anniversary Prize for Higher Education in 2014 in recognition of the impact of our research on healthcare.
The CPSD building was funded by peer-reviewed capital grants from the Wolfson Foundation and the Wellcome Trust and was officially opened in March 2020. The Centre provides 2000 M2 of research space, including a clinical research facility, laboratory support and housing for our cohort studies, clinical trials and biobanks. The CPSD currently has 40-50 research and support staff and is one of the most productive cerebrovascular research groups in the world.
What's new
Our researchers test ‘Viagra’ drug to prevent recurrent strokes
17 January 2020
Researchers in our Centre for the Prevention of Stroke and Dementia have begun a clinical trial to assess whether the drug sildenafil could improve blood flow to the brain.
Masonic Charitable Foundation Fund Studentship at Centre for the Prevention of Stroke and Dementia
13 September 2019
The charity has provided £126K of funding for one 3-year clinical research fellowship starting in January 2020.
Risk of dementia after TIA or stroke
2 May 2019
Risk of dementia after stroke is a major concern for patients and carers. Reliable data on risk of dementia, particularly after TIA or minor stroke, are scarce.
Research Projects
Selected Publications
Risks of recurrent stroke and all serious vascular events after spontaneous intracerebral haemorrhage: pooled analyses of two population-based studies
Li L. et al, (2021), The Lancet Neurology, 20, 437 - 447
Diagnosis of non-consensus transient ischaemic attacks with focal, negative, and non-progressive symptoms: population-based validation by investigation and prognosis
Tuna MA. and Rothwell PM., (2021), The Lancet, 397, 902 - 912
Risk of stroke in relation to degree of asymptomatic carotid stenosis: a population-based cohort study, systematic review, and meta-analysis.
Howard DPJ. et al, (2021), Lancet Neurol, 20, 193 - 202
Prognosis of Cryptogenic Stroke With Patent Foramen Ovale at Older Ages and Implications for Trials: A Population-Based Study and Systematic Review.
Mazzucco S. et al, (2020), JAMA neurology
Prevalence, predictors, and prognosis of symptomatic intracranial stenosis in patients with transient ischaemic attack or minor stroke: a population-based cohort study.
Hurford R. et al, (2020), Lancet Neurol, 19, 413 - 421
Head
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Peter Rothwell
Head of the Centre for the Prevention of Stroke and Dementia and Professor of Clinical Neurology
Stroke and heart disease research needs you!
Could you spare an hour to help our research?
Carotid Stenosis Tool
Helps to predict stroke risk