Wolfson Centre for Prevention of Stroke and Dementia
We increase understanding of the causes of cerebrovascular disease and improve the prevention of stroke and vascular dementia in routine clinical practice.
t: 01865 231601
The Stroke Prevention Research Unit was founded in 2000 by Professor Peter Rothwell with initial funding from the MRC and the Stroke Association.
Now comprising about 30 researchers and support staff, the centre is regarded as one of the most productive stroke research groups in the world. In summer 2019, it moves into a purpose-built new facility on the John Radcliffe Hospital site.
17 January 2020
Researchers in our Centre for the Prevention of Stroke and Dementia have begun a clinical trial to assess whether the drug sildenafil could improve blood flow to the brain.
13 September 2019
The charity has provided £126K of funding for one 3-year clinical research fellowship starting in January 2020.
2 May 2019
Risk of dementia after stroke is a major concern for patients and carers. Reliable data on risk of dementia, particularly after TIA or minor stroke, are scarce.
The Oxford Vascular Study (OxVasc) investigates vascular diseases (e.g. strokes, heart attacks) in patients registered with eight general practices in Oxfordshire. We run a rapid-access clinic for patients with suspected Transient Ischaemic Attacks (TIAs) or minor strokes. All OxVasc clinics held in the Wolfson Centre for the Prevention of Stroke and Dementia follow Oxford University Hospitals NHS Foundation Trust infection control guidelines.
CPSD runs several research studies looking into the causes, investigation, and management of large artery atherosclerosis, carotid stenosis, vertebral artery disease and intracranial atherosclerosis.
The Oxford Project to Investigate Memory and Ageing (OPTIMA) started in 1988 and the last LEAD participants were seen in March 2015. We are no longer recruiting to any of the cohorts. However, we are currently creating the OPTIMA Legacy Resource from which data collected from the OPTIMA cohorts is available and samples are biobanked and available. Brain tissue is available as part of the Brains For Dementia Research (BDR) collection.
Incidence and prevalence of dementia associated with transient ischaemic attack and stroke: analysis of the population-based Oxford Vascular Study.
Pendlebury ST. et al, (2019), Lancet Neurol, 18, 248 - 258
Prevalence of patent foramen ovale in cryptogenic transient ischaemic attack and non-disabling stroke at older ages: a population-based study, systematic review, and meta-analysis
Mazzucco S. et al, (2018), The Lancet Neurology, 17, 609 - 617
Medical Attention Seeking After Transient Ischemic Attack and Minor Stroke Before and After the UK Face, Arm, Speech, Time (FAST) Public Education Campaign
Wolters FJ. et al, (2018), JAMA Neurology
Effects of aspirin on risks of vascular events and cancer according to bodyweight and dose: analysis of individual patient data from randomised trials
Rothwell PM. et al, (2018), The Lancet, 392, 387 - 399
Age-specific risks, severity, time course, and outcome of bleeding on long-term antiplatelet treatment after vascular events: a population-based cohort study
Li L. et al, (2017), The Lancet, 390, 490 - 499