Infilration of a damaged nerve by Natural Killer cells.
Alexander J. Davies
B.Sc. (Hons), Ph.D.
UKRI Future Leaders Fellow
Dr Davies’ research focuses on understanding the pathophysiology of nerve injury and neuropathic pain.
He completed his PhD training in neurophysiology with Professor R. Alan North at the University of Manchester. During postdoctoral training at Seoul National University in South Korea his work led to discoveries in spinal mechanisms of neuropathic pain and a clinically-relevant treatment for dental pain. Subsequently, as a NRF Junior Research Fellow, he led a team of international collaborators to reveal a novel immune mechanism of axon degeneration after peripheral nerve injury.
Since moving to the University of Oxford, he has developed methods to study human neuro-immune interactions in vitro, and currently leads several pilot studies phenotyping immune cell function in patients recovering from nerve injury.
Dr Davies was recently awarded a prestigious UKRI Future Leaders Fellowship in which he will investigate the mechanisms of cellular cytotoxicity in immune-mediated recovery from nerve injury. His long-term goals are to translate these biological discoveries into novel immune therapies for neuropathic pain.
Davies AJ. et al, (2019), Cell, 176, 716 - 728.e18
Kim YH. et al, (2012), Neuron, 74, 640 - 647
In Vitro Visualization of Cell-to-Cell Interactions Between Natural Killer Cells and Sensory Neurons
Kim HW. et al, (2022), Natural Killer (NK) Cells., 2463, 251 - 268
Guillain-Barré syndrome following Zika virus infection is associated with a diverse spectrum of peripheral nerve reactive antibodies
Davies AJ. et al, (2021)
IgG1 pan-neurofascin antibodies identify a severe yet treatable neuropathy with a high mortality
Fehmi J. et al, (2021), Journal of Neurology, Neurosurgery & Psychiatry
Overlapping central and peripheral nervous system syndromes in MOG antibody-associated disorders
RINALDI S. et al, (2020), Neurology, Neuroimmunology and Neuroinflammation