Cristina Martinez

BSc PhD

Senior Postdoctoral Research Scientist

Research groups

Clinical Ophthalmology Research Group

Cristina’s background is in retinal diseases and pharmacological therapies. She obtained her PhD at the Health Research Institute of the La Fe University Hospital (Valencia, Spain), where she studied the role of oxidative stress and inflammation in the pathogenesis of retinitis pigmentosa and the effect of anti-TNFα antibodies as a pharmacological approach to delay photoreceptor death.

Cristina is engaged in ongoing research to develop gene therapies for currently incurable retinal diseases such as retinitis pigmentosa or macular dystrophies, using modified forms of adeno-associated virus (AAV) as vectors to deliver therapeutic genes to retinal cells.

Recent publications

Mirtron-mediated RNA knockdown/replacement therapy for the treatment of dominant retinitis pigmentosa
Journal article

Orlans HO. et al, (2021), Nature Communications, 12
Characterizing the Cellular Immune Response to Subretinal AAV Gene Therapy in the Murine Retina
Journal article

Chandler LC. et al, (2021), Molecular Therapy - Methods & Clinical Development
Accurate Quantification of AAV Vector Genomes by Quantitative PCR
Journal article

Martinez-Fernandez de la Camara C. et al, (2021), Genes, 12, 601 - 601
Inclusion of PF68 Surfactant Improves Stability of rAAV Titer when Passed through a Surgical Device Used in Retinal Gene Therapy.
Journal article

Patrício MI. et al, (2020), Mol Ther Methods Clin Dev, 17, 99 - 106
Retinal Gene Therapy in X-Linked Retinitis Pigmentosa Caused by Mutations in RPGR: Results at 6 Months in a First in Human Clinical Trial
Conference paper

Cehajic-Kapetanovic J. et al, (2020), MOLECULAR THERAPY, 28, 1 - 1
Initial results from a first-in-human gene therapy trial on X-linked retinitis pigmentosa caused by mutations in RPGR
Journal article

Cehajic-Kapetanovic J. et al, (2020), Nature Medicine, 26, 354 - 359
RPGR gene therapy presents challenges in cloning the coding sequence
Journal article

Martinez-Fernandez De La Camara C. et al, (2020), Expert Opinion on Biological Therapy, 20, 63 - 71
Molecular Strategies for RPGR Gene Therapy.
Journal article

Cehajic Kapetanovic J. et al, (2019), Genes (Basel), 10
Fundus autofluorescence abnormalities and microglia/macrophage activation in the Rpgr-deficient mouse
Conference paper

Staurenghi F. et al, (2019), INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 60
In vitro expression model for AAV2.VMD2.BEST1 gene therapy vectors
Conference paper

dela Camara CM-F. et al, (2019), INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 60

More publications