Cristina Martinez

BSc PhD

Postdoctoral Research Scientist and Knoop Junior Research Fellow, St Cross College

Cristina’s background is in retinal diseases and pharmacological therapies. She obtained her PhD at the Health Research Institute of the La Fe University Hospital (Valencia, Spain), where she studied the role of oxidative stress and inflammation in the pathogenesis of retinitis pigmentosa and the effect of anti-TNFα antibodies as a pharmacological approach to delay photoreceptor death.

Cristina is engaged in ongoing research to develop gene therapies for currently incurable retinal diseases such as retinitis pigmentosa or macular dystrophies, using modified forms of adeno-associated virus (AAV) as vectors to deliver therapeutic genes to retinal cells.

Recent publications

Inclusion of PF68 Surfactant Improves Stability of rAAV Titer when Passed through a Surgical Device Used in Retinal Gene Therapy.
Journal article

Patrício MI. et al, (2020), Mol Ther Methods Clin Dev, 17, 99 - 106
Initial results from a first-in-human gene therapy trial on X-linked retinitis pigmentosa caused by mutations in RPGR
Journal article

Cehajic-Kapetanovic J. et al, (2020), Nature Medicine
RPGR gene therapy presents challenges in cloning the coding sequence
Journal article

Martinez-Fernandez De La Camara C. et al, (2020), Expert Opinion on Biological Therapy, 20, 63 - 71
Molecular Strategies for RPGR Gene Therapy.
Journal article

Cehajic Kapetanovic J. et al, (2019), Genes (Basel), 10
A Quantitative Chloride Channel Conductance Assay for Efficacy Testing of AAV.BEST1.
Journal article

Wood SR. et al, (2019), Hum Gene Ther Methods, 30, 44 - 52
Misdiagnosis of X-linked retinitis pigmentosa in a choroideremia patient with heavily pigmented fundi
Journal article

Nanda A. et al, (2018), Ophthalmic Genetics, 39, 380 - 383
HIF-1α stabilization reduces retinal degeneration in a mouse model of retinitis pigmentosa
Journal article

Olivares-González L. et al, (2018), The FASEB Journal, 32, 2438 - 2451
Gene therapy for the treatment of X-linked retinitis pigmentosa
Journal article

Martinez-Fernandez De La Camara C. et al, (2018), Expert Opinion on Orphan Drugs, 6, 167 - 177
Codon-Optimized RPGR Improves Stability and Efficacy of AAV8 Gene Therapy in Two Mouse Models of X-Linked Retinitis Pigmentosa
Journal article

Fischer MD. et al, (2017), Molecular Therapy, 25, 1854 - 1865
cGMP-Phosphodiesterase Inhibition Prevents Hypoxia-Induced Cell Death Activation in Porcine Retinal Explants
Journal article

Olivares-González L. et al, (2016), PLOS ONE, 11, e0166717 - e0166717

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