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Livia Civitelli

DPhil in Developmental and Cell Biology


Postdoctoral Scientist in Molecular Neuroscience

Fascinated by Amyloidoisis, Protein folding, Aggregation pathways, Cell-to-cell spreading of amyloid protein aggregates.

BIOGRAPHY

After graduating from University of Rome "La Sapienza" (Italy) with degrees in Biological Science (BSc) and Molecular Biology (MSc), Livia obtained the PhD in Developmental and Cell Biology in 2005 in the University of Rome "La Sapienza" in collaboration with the École Normale Supérieure de Lyon (France).

From 2006 Livia has been investigating the neurodegenerative disorders, firstly, by studying the co-factorial role of Herpes simplex in the outcome of Alzheimer´s disease. She produced data demonstrating that Herpes simplex infections trigger the amyloid-beta precursor (Aβ) processing, leading to the accumulation of multiple neurotoxic fragments and that infections significantly increases the extracellular content of . She also demonstrated that Herpes simplex infections induce the formation of a DNA-binding fragment that regulates the expression of specific genes involved in the outcome of Alzheimer´s disease. 

From 2012-2017, Livia joined Linköping University (Sweden), where she started working on  from a biophysical point of view. Livia studied the aggregation pathway of  and the modulation of its toxic effect when aggregated together with luminescent conjugated oligothiophenes (LCOs). Livia demonstrated that the LCO pFTAA accelerates Aβ aggregation, thus counteracting Aβ cytotoxic effects. 

Livia´s research had also focused on cell-to-cell transfer of amyloid aggregates in both Alzheimer´s and Parkinson´s diseases via exosomes and/or diffusion and the possibility to impede either their uptake or the spreading among cells using specific antibodies as tools.

From 2018-2020, Livia studied at Linköping University where she obtained her second degree in Chemical Biology (MSc).

Recent publications

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