Contact information
+44 (0)1865 610 476
Directions to my office at the WIN-Annexe, Wolfson Building
https://orcid.org/0000-0003-3544-0711
WIN-Annexe, Wolfson Building, Headley Way, Headington, Oxford OX3 9DU, UK.
she/her
Team members
-
Julien Fars
Postdoctoral Research Fellow
-
Rebecca Willis
DPhil Student
-
Megan Groombridge
Research Assistant
Research groups
Collaborators
Oxford
Dr Beata Godlewska , Dept. Psychiatry
International
Dennis Levi, University of California, Berkeley, USA
Jun-Yun Zhang, Peking University, Peking, China
Generously funded by
Betina Ip
DPhil
Royal Society Dorothy Hodgkin Research Fellow
- Principal Investigator
- Hugh Price Fellow, Jesus College
Our research
How do we learn to see with two eyes?
Understanding the neural basis of binocular vision matters, because impaired binocular vision due to amblyopia, also known as ‘lazy eye’, is the most common vision problem in children. While the clinical dogma has been that amblyopia can only be treated in early childhood, we now know that adults with amblyopia can still improve their vision. We do not know how the brain supports this plasticity. If we can better understand how the brain combines images from two eyes, then we can use this knowledge to better treat amblyopia for more people.
My lab investigates the neural basis of binocular vision, from acquisition in early childhood to binocular vision in adulthood. We use perceptual tests and virtual reality to measure and train how well the two eyes work together. These measures are combined with advanced non-invasive brain imaging data, especially MR Spectroscopy, to establish the fundamental structure, function and neurochemistry of binocular vision in the human brain.
About me
I read for my DPhil on attentional modulation of binocular vision at St John’s College, Oxford. I then worked on fine-scale representations of binocular disparity in the human brain at the Department of Physiology, Anatomy and Genetics as a postdoc. Subsequently, I switched the focus of my research to neurochemistry during basic visual processing, prompting me to connect it to our binocular vision and the cortical signals that support it. In 2020, I was awarded a Royal Society Dorothy Hodgkin Research Fellowship to pursue these links. I moved to the Nuffield Department of Clinical Neurosciences, where my research group studies binocular vision plasticity in normally and abnormally sighted populations.
Positive Research Culture
Positive research culture has made a huge difference to my career as a female scientist with caregiving responsibilities and from a diverse cultural background. To contribute, I mentor for the BIPOC STEM network, supporting ethnically diverse students at the University; I plan and provide content for women’s career advancement as part of the Women in Clinical Neurosciences committee, and I have co-led the WIN Centre's Early Career Researcher's group from 2020-2022, organizing workshops and training to enhance researchers' careers.
Current students
Lucy Starling, Doctoral training project student 2024
Po-Chun Tseng, MSc Clinical and Therapeutic Neuroscience 2024
Rebecca Willis, WIN-NDCN (DPhil student) 2023
Sylvana Vilca-Melendez, Dept. Psychiatry (DPhil student, co-supervisor) 2022
Lab alumni
Dr Jacek Matuszewski, Visiting researcher 2022
Kathleen Tracey, FHS student 2021/22, Wadham College
Websites
-
KOALA Child amblyopia study
We are inviting contributors to help us improve our research
-
Adult amblyopia study
We are actively recruiting participants with amblyopia.
Colleges
An introduction to binocular vision and neurochemistry
- bio20200059.pdf
- PDF document 1.3 MB
Research opportunities
Unversity of Oxford project students
Medical / Biomedical Sciences undergraduate students at Oxford University are welcome to email me about possible FHS projects. Oxford MSc/DPhil graduate students are also welcome to get in touch about graduate rotation projects.
Student projects can range from analysing brain and behaviour data to using virtual reality to train vision.
Prospective national and international DPhil students
I would be pleased to hear from prospective graduates. Please send me your CV, information about your research interests and motivation. Further information on the DPhil in Clinical Neurosciences can be found here.
Postdoctoral and research assistant positions will be advertised here and on the University's job website.
Key publications
-
The relationship between visual acuity loss and GABAergic inhibition in amblyopia
Journal article
Ip IB. et al, (2024), Imaging Neuroscience
-
Investigating the neurochemistry of the human visual system using magnetic resonance spectroscopy
Journal article
IP IB. and BRIDGE H., (2021), Brain Structure and Function
-
Comparison of Neurochemical and BOLD Signal Contrast Response Functions in the Human Visual Cortex
Journal article
Ip IB. et al, (2019), The Journal of Neuroscience, 39, 7968 - 7975
-
Combined fMRI-MRS acquires simultaneous glutamate and BOLD-fMRI signals in the human brain
Journal article
Ip IB. et al, (2017), NeuroImage, 155, 113 - 119
Recent publications
-
Chronic neuropathic pain components in whiplash-associated disorders correlate with metabolite concentrations in the anterior cingulate and dorsolateral prefrontal cortex: a consensus-driven MRS re-examination
Journal article
Pinilla-Fernández I. et al, (2024), Frontiers in Medicine, 11
-
The relationship between visual acuity loss and GABAergic inhibition in amblyopia
Journal article
Ip IB. et al, (2024), Imaging Neuroscience
-
Universal Dynamic Fitting of Magnetic Resonance Spectroscopy
Journal article
CLARKE W. et al, (2023), Magnetic Resonance in Medicine
-
GABA and Glutamate in hMT+ Link to Individual Differences in Residual Visual Function After Occipital Stroke
Journal article
Willis HE. et al, (2023), Stroke, 54, 2286 - 2295
-
Universal Dynamic Fitting of Magnetic Resonance Spectroscopy
Preprint
Clarke WT. et al, (2023)