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Division of Clinical Neurology


Deputy Head

  • Michele Hu
    Michele Hu

    Professor of Clinical Neuroscience and Consultant Neurologist

    01865 231295

What do we do?

Diseases of the central nervous system include many of the most disabling conditions, such as multiple sclerosis (MS), stroke, motor neuron disease (MND), Alzheimer’s disease and Parkinson’s disease. These disorders have great cost to patients, their family and carers, and to society as a whole. 

We want to understand underlying disease mechanisms in order to treat these conditions effectively.

We are based in the West Wing of the John Radcliffe Hospital. This provides the perfect setting to share facilities, expertise and knowledge, as well as realise our goal of applying our learning in clinical practice.

Read the history of the Division of Clinical Neurology.

Research Groups

Autoimmune Neurology Group

Research, diagnostic and testing service of autoantibodies associated with neurological diseases.

Cerebellar Disease Group

Understanding Cerebellar Development and Disease

Cognitive Neurology Research Group

We want to understand how - and why - brain function can be disturbed to lead to poor memory and loss of motivation (apathy). Our aim is to develop new treatments for these conditions across a range of neurological disorders.

Congenital Myasthenia Service

We provide a nationally commissioned specialised service for the diagnosis and management of children and adults in whom a congenital myasthenic syndrome is suspected.

Diagnostic and Advisory Service for Neuromyelitis Optica

Neuromyelitis optica (NMO) is a rare disease causing inflammation in the spinal cord and optic nerves. The NMO service brings together expertise in diagnostics and clinical management to improve outcomes for this often isolated group of patients.

Diseases of Protein Glycosylation

Glycosylation is one of the most common and poorly understood forms of post-translational modification. Our aim is to understand the biochemical mechanisms underlying protein glycosylation, as well as decipher the roles that they play in health and disease.

Glioma Neurosurgery Research Group

Our research aims to understand the characteristics of individual brain tumours, combining cutting edge brain imaging, molecular neuropathology and neurosurgical techniques to develop personalized approaches for first-line cancer surgery.

Models of Brain Decision Networks

Our group uses computer simulations and mathematical analyses to understand the information processing and activity dynamics of brain networks underlying decision making. We use these models to investigate how neural circuits work in the healthy state, how their dynamics deteriorate in neurological disorders, and how their dynamics and information processing may be best restored by treatments.

Molecular Neurodegeneration Research Group

Our aim is to understand fundamental biological processes that could inform the development of targeted therapies and innovative biomarkers in neurodegenerative and neurogenetic disorders.

Multiple Sclerosis Clinical Trials Unit

Our group aims to deliver the highest quality translational and clinical research within both investigator- and commercial-led clinical trials with a focus on relieving the disease burden of MS to patients and their carers.

Neural Injury Group

Our aim is to gain a better understanding of the response of the peripheral nervous system to injury in order to develop strategies to promote peripheral nerve repair and to prevent the development of neuropathic pain. To do this we employ a variety of multi-disciplinary techniques ranging from transgenic models to human psychophysical studies and genetics.

Neuro-Endocrinology Research Group

This cross-disciplinary research group links neuropathology, endocrinology and molecular genetics to explore how the genetics and epigenetics of pituitary tumours influences clinical characteristics and to identify targets for therapeutic intervention.

Neurodegeneration and Inflammation Research Group

We explore the neuropathology of multiple sclerosis and other inflammatory and neurodegenerative diseases using a multidisciplinary team approach to post-mortem brain and spinal cord tissue. The aim is that the understanding derived from these studies will translate into ideas for improved treatments for living patients.

NeuroMetrology Lab

Our objective is to develop ways of accurately measuring neurological disorders such as Parkinson's disease.

Neuromuscular Disorders

We work to translate an understanding of the molecular mechanisms of disease at the neuromuscular synapse into treatments. Our work led us to be commissioned to provide a National Advisory and Diagnostic Service for congenital myasthenic syndromes.

Oxford Centre for Neuroinflammation

We bring together biomedical, analytical and clinical expertise to shed new light on the causes that underpin neurodegenerative diseases.

Oxford Epilepsy Research Group

We are a forward-looking dynamic group interested in all aspects of clinical and experimental epileptology with an emphasis on clinically relevant research. The Group draws together all relevant disciplines across Oxford University Hospitals and the University of Oxford.

Parkinson’s Neuropathology Group

We study why certain neuronal populations are vulnerable to neurodegeneration in Parkinson’s disease brain and whether pathological changes seen in the peripheral tissues mirror or precede what is ultimately seen in the brain, and how this can be used to develop biomarkers.